Sequence comparison identifies phylogeny-specific, paralogy-specific, and orthology-specific conserved motifs in ar-C sequences. Multiple alignment of ar-C homolog sequences of shh(a) and shhb genes of different vertebrate species was carried out. The phylogenetic tree on the left side represents the evolutionary relationship of the vertebrates. Species in blue correspond to ar-C of shh(a) genes, and those in red to ar-C of shhb genes. Dark blue boxes depict the conserved motifs, present in both shh(a) and shhb ar-C genes. Light-blue boxes mark motifs present only in shhb genes.
Hadzhiev et al. Genome Biology 2007 8:R106 doi:10.1186/gb-2007-8-6-r106