Research
Functional coordination of alternative splicing in the mammalian central nervous system
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* Corresponding authors: Brendan J Frey frey@psi.toronto.edu - Benjamin J Blencowe b.blencowe@utoronto.ca
- † Equal contributors
1 Banting and Best Department of Medical Research, Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada. M5S 3E1
2 Department of Molecular and Medical Genetics, Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada. M5S 3E1
3 Department of Electrical and Computer Engineering, University of Toronto, 40 St. George's Street, Toronto, Ontario, Canada
4 School of Computer Science and Engineering, Hebrew University, Jerusalem 91904, Israel
Genome Biology 2007, 8:R108 doi:10.1186/gb-2007-8-6-r108
Published: 12 June 2007Additional files
Additional data file 1:
Provided is supplemental information on genes with microarray detected tissue specific AS levels, additional details on Materials and Methods, and additional Figures (1-5).
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Additional data file 2:
Provided is information on tissue specific AS events.
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Additional data file 3:
Provided is information on CNS regulated AS events.
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Additional File 4:
Provided is information on correlated pairs of AS events belonging to the same genes.
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Additional data file 5:
Summarized are motifs associated with CNS specific AS events detected from ab initio searches.
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Additional data file 6:
Summarized are experimentally defined sequences/motifs associated with neural specific AS used for searches
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Additional data file 7:
Summarized are experimentally defined motifs/subsequences significantly enriched in exons and introns associated with CNS regulated AS events identified in the AS microarray data.
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Additional data file 8:
Summarized are the number and statistical significance of ab initio motifs detected at each exonic and intronic location, and in each group.
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Additional data file 9:
Summarized are motifs associated with CNS specific AS events detected by searching with the Improbizer program.
Format: PDF Size: 174KB Download file
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Additional data file 10:
Shown are conservation levels of motifs associated with CNS specific AS events detected from ab initio searches.
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Additional data file 11:
Provided are GenASAP values and C1-A-C2 exon sequences for 3,707 AS events profiled in 27 mouse tissues. Additional microarray data has been deposited in GEO under accession GSE8081.
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