Figure 4.

Network diagram comprising genes and functional processes associated with regulated AS events in the CNS. Experimental evidence supporting interactions, pathway and functional relationships among genes with microarray detected central nervous system (CNS) specific alternative splicing (AS) events was retrieved from the literature and from the Online Predicted Human Interaction Database [45], and used to construct a network diagram using the Osprey program [46]. Yellow nodes denote cytoskeletal pathways/genes, green nodes denote vesicle-mediated transport pathways/genes, red nodes denote signaling pathways/genes, and blue nodes denote CNS functions. Red edges denote protein-protein interactions, black edges denote gene-pathway associations, blue edges denote gene-CNS function associations, and gray edges denote pathway-pathway or pathway-CNS function associations. Pathways and CNS functions are in bold letters. Gene names are the NCBI Entrez Gene standard gene symbols.