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List of genes with CNS tissue-specific AS regulation |
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| Category |
Gene name |
Accession |
CNS function/phenotype |
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| Signaling |
Arhgef7 |
AF247655 |
Synapse formation |
| Camk2d |
BC042895 |
Phosphorylates PSD-95 in postsynaptic density |
|
| Camk2g |
BU560927 |
Phosphorylates PSD-95 in postsynaptic density |
|
| Git2 |
BU614137 |
Postsynaptic density interactions |
|
| Map4k6 |
BC011346 |
Axon guidance |
|
| Map3k4 |
AK122219 |
Neural tube development |
|
| Opa1 |
AK050383 |
Neuropathy |
|
| Plcb4 |
BC051068 |
Metabotropic glutamate neurotransmitter signaling pathway, synaptic depression |
|
| Ptprf |
AF300943 |
Synapse formation |
|
| Ptprk |
L10106 |
Neurite outgrowth |
|
| Rapgef6 |
BC019702 |
Neurogenesis, gliogenesis |
|
| Rap1ga1 |
BY234371 |
Neurite outgrowth |
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| Vav2 |
U37017 |
Neurite outgrowth |
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| Cytoskeleton |
Ablim1 |
AK122196 |
Axon guidance |
| Clasp1 |
CA326660 |
Axon guidance |
|
| Dst |
AK037206 |
Neurodegeneration, myelination, retrograde axonal transport |
|
| Kifap3 |
D50367 |
Axonal vesicle transport |
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| Myo5a |
CA469310 |
Synaptic vesicle transport |
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| Myo6 |
U49739 |
Neurotransmitter endocytosis |
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| Syne1 |
BC041779 |
Synaptic nuclear envelope anchor at neuromuscular junction |
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| Tmod2 |
AU035865 |
Learning/memory, long-term potentiation |
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| Vesicular transport |
Dlgh4 |
D50621 |
Synaptic vesicle maturation |
| Dnm1 |
BC034679 |
Synaptic vesicle endocytosis |
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| Exoc7 |
AF014461 |
Neurotransmitter receptor membrane targeting |
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| Rab6ip2 |
AF340029 |
Neurotransmitter release |
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| Snap23 |
AA450833 |
Neurotransmitter exocytosis |
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| Sgip1 |
BC017596 |
Neural energy balance regulation |
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| Syngr1 |
AK010442 |
Synaptic vesicle component |
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| mRNA processing |
Adarb1 |
AF525421 |
Glutamate receptor mRNA editing |
| Papola |
NM_011112 |
Regulated polyadenylation at synapses |
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| Transcription factors |
Apbb1 |
BM950527 |
Learning/memory, Alzheimer's disease |
| Nfatc3 |
BC021835 |
Axon outgrowth, neuronal survival, astrocyte function |
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| Tcf12 |
X64840 |
Transcription factor involved in neuronal plasticity, CNS development |
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| Tight junctions |
Baiap1 |
AK032350 |
Nervous system signaling |
| Magi3/6530407C02Rik |
AF213258 |
CNS signaling, neurotransmitter receptor regulation |
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| Tjp4 |
BU612515 |
Interacts with synaptic protein |
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| Ion channels |
P2rx4 |
AF089751 |
Neurotransmitter receptor |
| Slc24a2 |
NM_172426 |
Calcium ion channel in axon terminals |
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| Other functions |
Agrn |
BG803812 |
Regulates formation of postsynaptic structure at the neuromuscular junction |
| Kidins220/C330002I19Rik |
AK083260 |
Neural signaling |
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| Mgea6 |
BI962144 |
Meningioma antigen |
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| Mgrn1 |
BY567496 |
Neuronal degradation, astrocytosis |
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| Neo1 |
Y09535 |
Axon guidance, neuronal survival |
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| NIBP/1810044A24Rik |
BC034590 |
Neurite outgrowth, nerve growth factor signaling |
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| Pcmt1 |
AA981003 |
Memory, synaptic function, seizures |
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| Sca2 |
AF041472 |
Neurodegenerative disease spinocerebellar ataxia |
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| Serpinh1 |
BB613516 |
Glial cell protection, CNS development |
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Microarray-profiled genes displaying central nervous system (CNS) tissue specific alternative splicing regulation are listed, along with a description of known functions of the genes in the nervous system. More detailed information on the same gene list, including published information on the CNS tissue regulated exons and relevant literature, is provided in Additional data file 3. | |||
Fagnani et al. Genome Biology 2007 8:R108 doi:10.1186/gb-2007-8-6-r108 |
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