LongSAGE profiling of nine human embryonic stem cell lines

doi:10.1186/gb-2007-8-6-r113

Genome Biology

Volume 8
Issue 6

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Hirst M
Delaney A
Rogers SA
Schnerch A
Persaud DR
O'Connor MD
Zeng T
Moksa M
Fichter K
Mah D
Go A
Morin RD
Baross A
Zhao Y
Khattra J
Prabhu AL
Pandoh P
McDonald H
Asano J
Dhalla N
Ma K
Lee S
Ally A
Chahal N
Menzies S
Siddiqui A
Holt R
Jones S
Gerhard DS
Thomson JA
Eaves CJ
Marra MA

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Hirst M
Delaney A
Rogers SA
Schnerch A
Persaud DR
O'Connor MD
Zeng T
Moksa M
Fichter K
Mah D
Go A
Morin RD
Baross A
Zhao Y
Khattra J
Prabhu AL
Pandoh P
McDonald H
Asano J
Dhalla N
Ma K
Lee S
Ally A
Chahal N
Menzies S
Siddiqui A
Holt R
Jones S
Gerhard DS
Thomson JA
Eaves CJ
Marra MA
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LongSAGE profiling of nine human embryonic stem cell lines

Martin Hirst¹ , Allen Delaney¹ , Sean A Rogers¹ , Angelique Schnerch¹ , Deryck R Persaud¹ , Michael D O'Connor² , Thomas Zeng¹ , Michelle Moksa¹ , Keith Fichter¹ , Diana Mah¹ , Anne Go¹ , Ryan D Morin¹ , Agnes Baross¹ , Yongjun Zhao¹ , Jaswinder Khattra¹ , Anna-Liisa Prabhu¹ , Pawan Pandoh¹ , Helen McDonald¹ , Jennifer Asano¹ , Noreen Dhalla¹ , Kevin Ma¹ , Stephanie Lee¹ , Adrian Ally¹ , Neil Chahal¹ , Stephanie Menzies¹ , Asim Siddiqui¹ , Robert Holt¹ , Steven Jones¹ , Daniela S Gerhard³ , James A Thomson⁴ , Connie J Eaves² and Marco A Marra¹

¹Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, V5Z 1L3

²Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, V5Z 1L3

³National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

⁴Wisconsin National Primate Research Centre and Department of Anatomy, School of Medicine, University of Wisconsin, Madison, Wisconsin 53715, USA

author email corresponding author email

Genome Biology 2007, 8:R113doi:10.1186/gb-2007-8-6-r113


Published:	14 June 2007

Subject areas: Development, Molecular biology, Genome studies

Abstract

To facilitate discovery of novel human embryonic stem cell (ESC) transcripts, we generated 2.5 million LongSAGE tags from 9 human ESC lines. Analysis of this data revealed that ESCs express proportionately more RNA binding proteins compared with terminally differentiated cells, and identified novel ESC transcripts, at least one of which may represent a marker of the pluripotent state.