Research
Genome position and gene amplification
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* Corresponding author: Donna G Albertson albertson@cc.ucsf.edu
1 Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143-0808, USA
2 Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143-0808, USA
3 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143-0808, USA
4 Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143-0808, USA
5 Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská, Brno, 612 65, Czech Republic
Genome Biology 2007, 8:R120 doi:10.1186/gb-2007-8-6-r120
Published: 21 June 2007Additional files
Additional data file 1:
Mapping and sequencing of DHFR* integration sites
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Additional data file 2:
Array CGH log2 ratio data on clones for methotrexate resistant colonies and untreated DHFR* integrants
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Additional data file 3:
DHFR* was integrated on chromosome 8 at 102,162,871 bp and this position is highlighted in red. All five colonies formed amplicons around the DHFR* integration site. Amplified regions are highlighted in yellow.
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Additional data file 4:
Expression array data
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Additional data file 5:
Expression of genes mapping in amplicons in 12 methotrexate resistant cell lines
Format: XLS Size: 447KB Download file
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Additional data file 6:
Comparison of analysis of array data with and without spatial and GC correction
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Additional data file 7:
Example of elucidation of copy number changes specific to methotrexate resistant cells (results of the analyses for the 1M-34_c5a colony)
Format: PDF Size: 65KB Download file
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