Table 1 |
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The Pfam domains having many combination partners in animal-specific combinations |
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| Pfam ID |
Number of partners |
Group specificity |
Definition |
|
|
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| Pkinase |
37 |
Com |
Protein kinase domain |
| SH2 |
19 |
Euk |
SH2 domain |
| Laminin_EGF |
18 |
Euk |
Laminin EGF-like (domains III and V) |
| C1_1 |
17 |
Euk |
Phorbol esters/diacylglycerol binding domain (C1 domain) |
| RA |
12 |
Euk |
Ras association (RalGDS/AF-6) domain |
| Spectrin |
11 |
Euk |
Spectrin repeat |
| PSI |
11 |
Euk |
Plexin repeat |
| C1_3 |
10 |
Euk |
C1-like domain |
| PID |
09 |
Ani |
Phosphotyrosine interaction domain (PTB/PID) |
| Homeobox |
09 |
Euk |
Homeobox domain |
| zf-B_box |
08 |
Euk |
B-box zinc finger |
| LRRNT |
08 |
Ani |
Leucine rich repeat amino-terminal domain |
| zf-MYND |
07 |
Euk |
MYND finger |
| RasGEF |
07 |
Euk |
RasGEF domain |
| DEAD |
07 |
Com |
DEAD/DEAH box helicase |
| cNMP_binding |
06 |
Com |
Cyclic nucleotide-binding domain |
| Y_phosphatase |
06 |
Euk |
Protein-tyrosine phosphatase |
| WAP |
06 |
Ani |
WAP-type (whey acidic protein) 'four-disulfide core' |
| UBA |
06 |
Com |
UBA/TS-N domain |
| ResIII |
06 |
Com |
Type III restriction enzyme, res subunit |
| PWWP |
06 |
Euk |
PWWP domain |
| MIB_HERC2 |
06 |
Euk |
Mib_herc2 |
| LRRCT |
06 |
Ani |
Leucine rich repeat carboxyl-terminal domain |
| LIM |
06 |
Euk |
LIM domain |
| KH_1 |
06 |
Com |
KH domain |
| HECT |
06 |
Euk |
HECT-domain (ubiquitin-transferase) |
| DUF1136 |
06 |
Ani |
Repeat of unknown function (DUF1136) |
| Band_41 |
06 |
Euk |
FERM domain (Band 4.1 family) |
|
|
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Shown are hub domains preferentially found in animal-specific combinations. We defined hub domains that are preferentially found in animal-specific combinations as those found in animal-specific combinations more than twice as frequently as in deuterostome-specific combinations. Regarding the group specificity of the domains, the terms 'Euk', 'Ani', and 'Deu' refer to eukaryote, animal, and deuterostome, respectively. 'Com' indicates that the domain is shared by prokaryotes and eukaryotes. |
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Itoh et al. Genome Biology 2007 8:R121 doi:10.1186/gb-2007-8-6-r121 |
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