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The Pfam domains having many combination partners in deuterostome-specific combinations |
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| Pfam ID |
Number of partners |
Group specificity |
Definition |
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| VWA |
14 |
Com |
von Willebrand factor type A domain |
| WD40 |
13 |
Euk |
WD domain, G-beta repeat |
| MAM |
12 |
Euk |
MAM domain |
| SAM_2 |
11 |
Euk |
SAM domain (sterile alpha motif) |
| Lectin_C |
11 |
Euk |
Lectin C-type domain |
| Kunitz_BPTI |
11 |
Ani |
Kunitz/Bovine pancreatic trypsin inhibitor domain |
| Collagen |
11 |
Euk |
Collagen triple helix repeat (20 copies) |
| WW |
10 |
Euk |
WW domain |
| TIL |
10 |
Ani |
Trypsin Inhibitor like cysteine rich domain |
| IQ |
10 |
Euk |
IQ calmodulin-binding motif |
| Trypsin |
09 |
Com |
Trypsin |
| GPS |
08 |
Ani |
Latrophilin/CL-1-like GPS domain |
| GCC2_GCC3 |
08 |
Euk |
GCC2 and GCC3 |
| Death |
08 |
Ani |
Death domain |
| CH |
08 |
Euk |
Calponin homology (CH) domain |
| zf-RanBP |
07 |
Euk |
Zn-finger in Ran binding protein and others |
| fn2 |
07 |
Deu |
Fibronectin type II domain |
| Xlink |
07 |
Deu |
Extracellular link domain |
| F5_F8_type_C |
07 |
Euk |
F5/8 type C domain |
| zf-CCCH |
06 |
Euk |
Zinc finger C-x8-C-x5-C-x3-H type (and similar) |
| Kringle |
06 |
Euk |
Kringle domain |
| Kazal_2 |
06 |
Euk |
Kazal-type serine protease inhibitor domain |
| Kazal_1 |
06 |
Euk |
Kazal-type serine protease inhibitor domain |
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Shown are hub domains preferentially found in deuterostome-specific combinations. We defined hub domains that are preferentially found in deuterostome-specific combinations as those found in deuterostome-specific combinations more than twice as frequently as in animal-specific combinations. Regarding the group specificity of the domains, the terms 'Euk', 'Ani', and 'Deu' refer to eukaryote, animal, and deuterostome, respectively. 'Com' indicates that the domain is shared by prokaryotes and eukaryotes. | |||
Itoh et al. Genome Biology 2007 8:R121 doi:10.1186/gb-2007-8-6-r121 |
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