Research
Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity
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* Corresponding author: Jonathan H Freedman freedma1@niehs.nih.gov
1 Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708, USA
2 Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
3 Laboratory of Environmental Lung Disease, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
4 Department of Medicine, Duke University Medical Center, Durham, NC 27707, USA
Genome Biology 2007, 8:R122 doi:10.1186/gb-2007-8-6-r122
Published: 25 June 2007Additional files
Additional data file 1:
Cadmium-responsive genes that have been mapped to biological processes and molecular functions following 4 and 24 h cadmium exposures.
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Additional data file 2:
Genes up- or down-regulated (≥1.5 fold, p < 0.001) following 4 h and 24 h cadmium exposures.
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Additional data file 3:
Significantly enriched biological processes following 4 h and 24 h cadmium exposures and genes in the pathway that are cadmium-responsive.
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Additional data file 4:
Significantly enriched molecular functions following 4 h and 24 h cadmium exposures and genes in the pathway that are cadmium-responsive.
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Additional data file 5:
Cadmium-responsive genes tested in the first round RNAi screen.
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Additional data file 6:
Effect of RNAi and cadmium on C. elegans body size in the second round RNAi screen using COPAS BioSort.
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Additional data file 7:
Primer sequences used in qRT-PCR.
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