Figure 5.

Protein interaction analysis using Cytoscape. High confidence interactions from yeast two-hybrid screens and the literature are displayed with solid blue lines; low confidence interactions from yeast two-hybrid screens are displayed with dashed blue lines; and predicted interactions are displayed with yellow lines. (a) Local networks involved in cadmium sensitivity. The network was filtered by showing nodes that were significantly up-regulated (red) or down-regulated (green) following a 24 h exposure to cadmium (≥1.5 fold, p ≤ 0.001) and their first neighbors (white). The identified genes are those that affect cadmium sensitivity in the RNAi experiments. (b) The BRP-1-Y46G5A.24-KEL-8 interaction network. Immediate and secondary neighbors of Y46G5A.24 are displayed.