Genome Biology

official impact factor 6.89

Open Access Research

Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome

Noa Sela1, Britta Mersch2, Nurit Gal-Mark1, Galit Lev-Maor1, Agnes Hotz-Wagenblatt2 and Gil Ast1*

Author Affiliations

1 Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel

2 HUSAR Bioinformatics Lab, Department of Molecular Biophysics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, D-69120 Heidelberg, Germany

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Genome Biology 2007, 8:R127 doi:10.1186/gb-2007-8-6-r127

Published: 27 June 2007

Additional files

Additional data file 1:

Presented is a table describing the number of exonizations based on the existence of two ESTs/cDNA.

Format: DOC Size: 62KB Download file

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Additional data file 2:

Presented is a table of all χ2 test P values of all TE exonization levels.

Format: DOC Size: 22KB Download file

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Additional data file 3:

Presented is a table of statistical χ2 test P values for the preference of all TE exonizations in the sense/antisense orientation.

Format: DOC Size: 45KB Download file

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Additional data file 4:

Presented 4 is a table of statistical χ2 test P values for the preference of all TE exonizations in the UTR.

Format: DOC Size: 48KB Download file

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Additional data file 5:

Presented is an example of Alu exonization within a non-protein-coding gene.

Format: DOC Size: 222KB Download file

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Additional data file 6:

Presented is an illustration showing alignment of mouse L1 (Lx8) and human L1 (L1MC4).

Format: DOC Size: 54KB Download file

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Additional data file 7:

Presented is an illustration showing the populations of different families of L1 within human and mouse.

Format: DOC Size: 42KB Download file

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Additional data file 8:

Presented is a table of cDNA and EST accessions, confirming the noncanonical 3' splice site of the alternative intron within CWF19L1 gene.

Format: DOC Size: 43KB Download file

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Additional data file 9:

Presented is a table showing the domains contributed by TE exons.

Format: DOC Size: 42KB Download file

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Additional data file 10:

Presented is a table of tissue and cancer-specific TEs.

Format: DOC Size: 89KB Download file

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Additional data file 11:

Presented is a table of the potential splice sites of all TEs.

Format: DOC Size: 77KB Download file

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Additional data file 12:

Presented is an illustration showing RT-PCR of ACAD9 Alu exonization in different human cell lines.

Format: DOC Size: 184KB Download file

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Additional data file 13:

Presented is an Excel file containing coordinates of all tissue-specific and cancer specific exons in both human and mouse.

Format: XLS Size: 52KB Download file

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