Genome Biology
Volume 8
Issue 6

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Sela N
Mersch B
Gal-Mark N
Lev-Maor G
Hotz-Wagenblatt A
Ast G

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Mersch B
Gal-Mark N
Lev-Maor G
Hotz-Wagenblatt A
Ast G
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Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome

Noa Sela¹ , Britta Mersch² , Nurit Gal-Mark¹ , Galit Lev-Maor¹ , Agnes Hotz-Wagenblatt² and Gil Ast¹

¹Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel

²HUSAR Bioinformatics Lab, Department of Molecular Biophysics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, D-69120 Heidelberg, Germany

author email corresponding author email

Genome Biology 2007, 8:R127doi:10.1186/gb-2007-8-6-r127


Published:	27 June 2007

Subject areas: Molecular biology, Genome studies, Evolution

Additional files

Additional data file 1:

Presented is a table describing the number of exonizations based on the existence of two ESTs/cDNA.

Format: DOC Size: 62KB Download file

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Additional data file 2:

Presented is a table of all χ²test P values of all TE exonization levels.

Format: DOC Size: 22KB Download file

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Additional data file 3:

Presented is a table of statistical χ²test P values for the preference of all TE exonizations in the sense/antisense orientation.

Format: DOC Size: 45KB Download file

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Additional data file 4:

Presented 4 is a table of statistical χ²test P values for the preference of all TE exonizations in the UTR.

Format: DOC Size: 48KB Download file

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Additional data file 5:

Presented is an example of Alu exonization within a non-protein-coding gene.

Format: DOC Size: 222KB Download file

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Additional data file 6:

Presented is an illustration showing alignment of mouse L1 (Lx8) and human L1 (L1MC4).

Format: DOC Size: 54KB Download file

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Additional data file 7:

Presented is an illustration showing the populations of different families of L1 within human and mouse.

Format: DOC Size: 42KB Download file

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Additional data file 8:

Presented is a table of cDNA and EST accessions, confirming the noncanonical 3' splice site of the alternative intron within CWF19L1 gene.

Format: DOC Size: 43KB Download file

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Additional data file 9:

Presented is a table showing the domains contributed by TE exons.

Format: DOC Size: 42KB Download file

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Additional data file 10:

Presented is a table of tissue and cancer-specific TEs.

Format: DOC Size: 89KB Download file

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Additional data file 11:

Presented is a table of the potential splice sites of all TEs.

Format: DOC Size: 77KB Download file

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Additional data file 12:

Presented is an illustration showing RT-PCR of ACAD9 Alu exonization in different human cell lines.

Format: DOC Size: 184KB Download file

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Additional data file 13:

Presented is an Excel file containing coordinates of all tissue-specific and cancer specific exons in both human and mouse.

Format: XLS Size: 52KB Download file

This file can be viewed with: Microsoft Excel Viewer