Additional data file 1:

Lists of probe sets and gene names altered by strain (3457) and morphine treatment (661) as well as with significant interaction (48) are available as separate sheets. List of transcripts with differences in both the factors (178) was also included. In addition, genes reported in previous gene expression studies on morphine action in a brain are indicated.

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Additional data file 2:

The results were obtained using fold change (>1.2) of gene expression level compared with the saline control group. Effects of morphine treatment were analyzed in all of the strains as well as separately in each of them. Numbers of probe sets correspond to those in Table 2.

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Additional data file 3:

Presented are significant functional categories (GO terms) enriched with genes regulated in response to acute and/or chronic morphine, along with lists of probe sets and gene names classified to each GO category.

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Additional data file 4:

Results for selected genes are presented as mean (± standard error) compared with the saline control group. List of Taqman assays used in qPCR experiments with ID and exon boundaries is included.

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Additional data file 5:

The expression level (MBEI PM/MM algorithm) of genes altered by acute and/or chronic morphine (699 probe sets) and behavioral data were normalized using z-score transformation. Associations were computed using the Pearson's correlation.

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