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Summary of morphine-induced changes in gene expression level in the four inbred strains |
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| Treatment |
Fold change over control |
All of the four strains |
129P3/J strain |
C57BL/6J strain |
DBA/2J strain |
SWR/J strain |
|
|
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| Acute upregulation |
>1.2a |
181 |
179 |
106 |
313 |
255 |
| >1.5 |
38 |
33 |
39 |
81 |
42 |
|
| Acute downregulation |
>1.2 |
69 |
44 |
108 |
68 |
67 |
| >1.5 |
6 |
4 |
25 |
25 |
14 |
|
| Chronic upregulation |
>1.2 |
76 |
90 |
116 |
59 |
63 |
| >1.5 |
13 |
17 |
38 |
8 |
10 |
|
| Chronic downregulation |
>1.2 |
145 |
83 |
278 |
98 |
141 |
| >1.5 |
9 |
9 |
61 |
10 |
12 |
|
|
The mouse strains evaluated were 129P3/J, C57BL/6J, DBA/2J, and SWR/J. aAnalysis was performed for the group of transcripts significantly changed after morphine treatment. Relative expression levels for 661 probe sets were computed using MBEI perfect match/mismatch (PM/MM) data. | ||||||
Korostynski et al. Genome Biology 2007 8:R128 doi:10.1186/gb-2007-8-6-r128 |
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