|
Examples of significantly enriched GO annotation for the list of morphine-responsive genes |
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| Mouse strain |
Morphine treatment |
mRNA change |
Enriched GO annotation (GO ID) |
Number of genes |
P |
Example genes |
|
|
||||||
| C57BL/6J |
Acute |
+a |
Regulation of apoptosis (0042981) |
11 |
9.1 × e-06b |
Tsc22d3, Pmaip1, and Plekhf1 |
| 129P3/J |
Chronic |
- |
Nucleosome assembly (0006334) |
5 |
1.7 × e-04 |
Hist1h1c, Hist1h3b, and Hist1h2bl |
| C57BL/6J |
Chronic |
- |
Transmission of nerve impulse (0019226) |
10 |
8.6 × e-04 |
Sncaip, Adora2a, and Npy5r |
| DBA/2J |
Acute |
+ |
Response to abiotic stimulus (0009628) |
15 |
9.8 × e-04 |
Cryab, Dnajb1, and Cdkn1a |
| DBA/2J |
Acute |
+ |
Response to temperature stimulus (0009266) |
5 |
1.7 × e-03 |
Hspa8, Hspa1b, and Cryab |
| C57BL/6J |
Chronic |
- |
Cellular lipid metabolism (0044255) |
17 |
1.95 × e-04 |
Vldr, Sc5d, and Acsl3 |
| SWR/J |
Acute |
+ |
Glucose transport (0015758) |
4 |
2.0 × e-03 |
Stxbp3a, Stxbp4, and Aps |
| SWR/J |
Chronic |
- |
Cell communications (0007154) |
25 |
2.3 × e-03 |
Plcd4, Gjb1, and Utrn |
| 129P3/J |
Acute |
- |
Neuron differentiation (0030182) |
5 |
2.4 × e-03 |
Olig2, Gli3, and Ablim1 |
| SWR/J |
Acute |
+ |
Carboxylic acid metabolism (0019752) |
16 |
1.4 × e-03 |
Cpt1a, Cpt2, and Crot |
| C57BL/6J |
Chronic |
+ |
Negative regulation of biological process (0048519) |
12 |
7.5 × e-03 |
Zbtb16, Sgk3, and Adrb1 |
| SWR/J |
Acute |
- |
Nervous system development (0007399) |
7 |
9.9 × e-03 |
Olig2, Rgma, and Ugt8a |
| 129P3/J |
Chronic |
+ |
Intracellular signaling cascade (0007242) |
12 |
1.0 × e-02 |
Ppm1, Dab1, and Snx24 |
|
The complete results of the Gene Ontology (GO) analysis are presented in Additional data file 3. a(+) increased mRNA abundance in response to morphine; (-) decreased mRNA level. bStatistical significance of functional over-representation was computed using Fisher's exact test. | ||||||
Korostynski et al. Genome Biology 2007 8:R128 doi:10.1186/gb-2007-8-6-r128 |
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