A small RNA makes a Bic difference
1 Cancer Immunology and AIDS, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
2 Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA
Genome Biology 2007, 8:221 doi:10.1186/gb-2007-8-7-221Published: 31 July 2007
The first highly specific knockouts of a microRNA, miR155, in mice result in multiple defects in adaptive immunity, and also show the feasibility of investigating at least some microRNAs by gene knockout.