Genome Biology

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A proteome-wide protein interaction map for Campylobacter jejuni

Jodi R Parrish1, Jingkai Yu1, Guozhen Liu1, Julie A Hines1, Jason E Chan3, Bernie A Mangiola1, Huamei Zhang1, Svetlana Pacifico1, Farshad Fotouhi4, Victor J DiRita5, Trey Ideker3, Phillip Andrews6 and Russell L Finley1,2*

Author Affiliations

1 Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA 48201

2 Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA 48201

3 Department of Bioengineering and Program in Bioinformatics, University of California at San Diego, San Diego, CA, USA 92093

4 Department of Computer Science, Wayne State University, Detroit, MI, USA 48201

5 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA 48109

6 Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA 48109

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Genome Biology 2007, 8:R130 doi:10.1186/gb-2007-8-7-r130

Published: 5 July 2007

Additional files

Additional data file 1:

Proteome coverage from large-scale interaction screens

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Additional data file 2:

Representation of functional categories amongst the proteins in the CampyYTH v3.1 dataset

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Additional data file 3:

GO category representation amongst the proteins in CampyYTH v3.1

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Additional data file 4:

C. jejuni genes that were toxic or inhibitory to yeast growth

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Additional data file 5:

Comparison of network features across organisms

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Additional data file 6:

Conserved subnetworks between C. jejuni and E. coli or C. jejuni and yeast

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Additional data file 7:

Predicted C. jejuni protein interactions

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Additional data file 8:

Higher resolution version of Figure 5, showing hierarchical clustering of conserved subnetworks

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Additional data file 9:

Enriched functions within the cores and modules of Figure 5

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Additional data file 10:

GO enrichment amongst the C. jejuni protein interactions

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Additional data file 11:

Essential proteins interact with each other more often than expected by chance

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Additional data file 12:

C. jejuni interologs predicted from large-scale protein interaction analyses performed for E. coli or H. pylori

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Additional data file 13:

Annotated list of all C. jejuni protein interactions in the CampyYTH v3.1 dataset

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Additional data file 14:

Supplementary materials and methods

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