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Detailed cluster analysis: differential and statistically significant biological functions in clusters C8-C10 |
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| Cluster no. |
Number of PS |
Reference |
Biology |
Example genes |
|
|
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| 8 |
1,240 |
Adult |
RNA post-transcriptional modification, cell cycle, cellular assembly and organization, DNA replication/recombination/repair, cancer, molecular transport, protein traffic and synthesis, cellular development, gastrointestinal disease, IGF-1 signaling, Wnt-signaling |
Mitosis (Ask, Birc5, Bcra1, Cdc2, Cdk4, Chek1, Mad2l1, Mif, Plk1), DNA mismatch repair (Hgmb1, Msh2, Pcna, Rev1l, Xrcc5), cell transformation (Cdc37, Id2, Myc), cell proliferation (Ctnnb1, Pcna, Plat, Plk1, Rala, Top2a), colorectal cancer (Birc5, Brca1, Cdc37, Myc, Top53), IGF-1 signaling (Igf1, Igfb4, Mapk1, Prkc, Ptpn11), Wnt signaling (Csnk1a1, Csnk2a1, Ctnnb1, Gs3kb, Myc, Nlk, Tcf3, Tcf4) |
| 9 |
1,676 |
Adult |
Protein synthesis, RNA-post transcriptional modification, cancer, connective tissue development and function, embryonic development, organ morphology, tissue morphology, cell-to-cell signaling and interaction, tissue development |
Protein synthesis (Csf1, Eif5, Gadd45g, Itgb1, Sars, Tnf, Traf6), transformation (Ccnd1), formation of hepatoma cell line (Hras, Pin1, Shfm1), cell growth (Nrp1, Tnf), invasion of lymphoma cell line (Itgb1, Itgb2), proliferation of ovarian cancer cell lines (Fst, Hras, Itgfb5, Sod2, Sparc), fibroblast cell cycle progression (Ccnf, E2f5, Hras, Map4, Rhoa, Skil), survival of epiblast (Dag1, Itgb1), cell adhesion (Icam1, Itgb1, Itgb2, Lu, Rhoa, Tnf) |
| 10 |
1,051 |
Adult |
Cell cycle, cellular assembly and organization, DNA replication, recombination/repair, cellular function and maintenance, cancer, cardiovascular system development and function, gene expression, immunological disease, digestive system development and function, activin/inhibin signaling |
Cell cycle (Cdk2, Ccnd3, Siah), exocytosis (Nos3, Snap23, Stx6, Vamp2), Burkitt's lymphoma (Dmtf1), cell transformation (Mmp2, Pecam1), angiogenesis (Mdk, Nos3), activation of RNA (Hrsp12, Rps6kb1), development of gastrointestinal tract (Pdgfra, Sptbn1), activin/inhibin signaling (Acvr2b, Bmpr1b, Inha, Map3k7, Mapk8, Tgfbr1) |
|
PS, ProbeSets. | ||||
Kaiser et al. Genome Biology 2007 8:R131 doi:10.1186/gb-2007-8-7-r131 |
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