Table 5

Mouse models of colon cancer

Model

Mm strain

N

Tumor-generating laboratory

Azoxymethane (AOM)

A × B

14

Threadgill

Apc^Min/+

(SWR × B6) F1

2

Dove

Apc^Min/+

(BR × B6) F1

2

Dove

Apc^Min/+

C57BL/6

5

Groden

Smad3^-/-

129

6

Graff

Smad3^-/-

129

7

Coffey

Tgfb1^-/-; Rag2^-/-

C57BL/6

3

Doetschman

Tumors from four established mouse models of CRC (Apc^Min/+, AOM, Smad3^-/- and Tgfb1^-/-; Rag2^-/- were analyzed. The table provides details on the mouse strains used for the four models, as well as information on the number of samples generated per model and sample-originating laboratory.

Kaiser et al. Genome Biology 2007 8:R131   doi:10.1186/gb-2007-8-7-r131