Open Access Research

Evolutionary conservation of regulated longevity assurance mechanisms

Joshua J McElwee1,2†, Eugene Schuster3†, Eric Blanc3†, Matthew D Piper1, James H Thomas2, Dhaval S Patel1, Colin Selman4, Dominic J Withers4, Janet M Thornton3, Linda Partridge1 and David Gems1*

1 Department of Biology, University College London, London WC1E 6BT, UK

2 Department of Genome Sciences, University of Washington, Seattle, Washington 98195-5065, USA

3 European Bioinformatics Institute, Hinxton CB10 1SD, UK

4 Department of Medicine, University College London, London WC1E 6BT, UK

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Genome Biology 2007, 8:R132 doi:10.1186/gb-2007-8-7-r132

Published: 5 July 2007

Additional files

Additional data file 1:

Legends for Additional data files 2-9

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Additional data file 2:

Phylogenetic trees for the four main families of drug metabolizing enzymes for C. elegans, Drosophila and mouse

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Additional data file 3:

Table 1: results of tests for over-representation of ortholog and paralog sets with parallel changes in gene expression. Table 2: identities of genes in four paralog sets with parallel changes in gene expression in C. elegans, Drosophila and the Little mouse.

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Additional data file 4:

Orthologs used in this study

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Additional data file 5:

Results of RNAi lifespan experiments

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Additional data file 6:

Output of the Catmap analysis of the microarray data

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Additional data file 7:

Summary of the results of statistical tests for over-representation of gene categories identified by the Catmap analysis

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Additional data file 8:

Output of Clover analysis for gene regulatory motifs for each dataset

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Additional data file 9:

Final gene lists from our analysis or reanalysis of microarray data

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