Different determinants of longevity may be public, semi-public or private. Our results suggest that public regulators of lifespan regulate semi-public mechanisms of longevity assurance, which may in turn act on a combination of private and public mechanisms of aging. The semi-public character of longevity assurance processes is reflected by the IIS-regulated gene classes. Several are linked to detoxification (such as the GSTs), and are the results of copious lineage-specific expansions.
McElwee et al. Genome Biology 2007 8:R132 doi:10.1186/gb-2007-8-7-r132