Table 5

Process-level conservation of IIS-regulated transcriptional responses

Catmap p value


Worm

Fly

Mouse


daf-2

chico

Ames

Little


Up-regulated Gene Ontology categories

GO:0008150 biological process

GO:0046365 monosaccharide catabolism

***

**

*

NS

GO:0019320 hexose catabolism

***

**

*

NS

GO:0006007 glucose catabolism

***

**

*

NS

GO:0006090 pyruvate metabolism

*

*

**

*

GO:0006091 generation of precursor metabolites

*

***

***

***

GO:0015980 energy derivation by oxidation

***

**

*

**

GO:0006092 main pathways of carbohydrate metabolism

***

**

**

**

GO:0015849 organic acid transport

*

*

*

NS

GO:0046942 carboxylic acid transport

*

*

*

NS

GO:0005975 carbohydrate metabolism

**

***

**

***

GO:0044262 cellular carbohydrate metabolism

***

***

*

**

GO:0016052 carbohydrate catabolism

**

**

*

NS

GO:0044275 cellular carbohydrate catabolism

**

**

*

NS

GO:0003674 molecular function

GO:0016491 oxidoreductase activity

***

***

***

***

GO:0016705 oxidoreductase activity with incorporation or reduction of molecular oxygen

*

**

NS

*

Up-regulated Interpro categories

IPR000073 Alpha-beta hydrolase fold

*

*

NS

*

IPR001128 Cytochrome P450

***

***

*

NS

IPR002198 Short-chain dehydrogenase/reductase SDR

**

***

NS

**

IPR002347 Glucose-ribitol dehydrogenase

***

***

NS

***

IPR004045 Glutathione-S-transferase N-terminal

**

***

***

***

IPR004046 Glutathione-S-transferase C-terminal

**

***

***

***

Down-regulated Gene Ontology categories

GO:0008150 biological process

GO:0009059 macromolecular biosynthesis

*

***

**

*

GO:0006412 protein biosynthesis

**

***

***

**

GO:0043037 translation

*

***

*

NS

GO:0046907 intracellular transport

***

*

NS

*

GO:0006605 protein targeting

**

**

**

NS

GO:0006996 organelle organization and biogenesis

**

***

NS

*

GO:0007010 cytoskeleton organization/biogenesis

*

***

NS

*

GO:0007017 microtubule-based process

**

*

NS

*

GO:0009790 embryonic development

***

***

NS

*

GO:0043283 biopolymer metabolism

***

***

NS

*

GO:0003674 molecular function

GO:0005488 binding

***

***

NS

*

GO:0003676 nucleic acid binding

*

***

NS

*

GO:0008135 translation factor, nucleic acid binding

*

***

NS

**

GO:0045182 translation regulator activity

*

***

NS

**

Down-regulated Interpro categories

IPR000980 SH2 motif

***

***

*

NS

IPR002111 Cation not K+ channel TM region

*

*

NS

*


This table shows the functional categories that are significantly up- or down-regulated in response to reduced IIS in the worm, fly, and mouse (Ames and/or Little) microarray datasets. For brevity, the full hierarchy of the significant GO categories has not been shown. GO categories that fall directly under another significant category within the hierarchy are shown indented under the relevant category. Categories that fall into more than one hierarchy are only shown in one representative hierarchy. NS (non-significant; p > 0.05); *p < 0.05; **p < 0.005; ***p < 5.0e-04.

McElwee et al. Genome Biology 2007 8:R132   doi:10.1186/gb-2007-8-7-r132

Open Data