Table 6

Expression of SOD genes in mutant worms, flies, mice with reduced insulin/IGF-1 signaling

C. elegans

Drosophila

Mouse




Prop-1df/df (Ames)

Ghrhrlit/lit (Little)



Log2 FC

q

Log2 FC

q

Log2 FC

q

Log2 FC

q



Cu/Zn SOD (IC)

sod-1

0.66

0.073

Sod1

0.10

0.219

Sod1

0.01

0.957

Sod1

-0.12

0.616

sod-5

2.14

0.006

Cu/Zn SOD (EC)

sod-4

0.58

0.339

Sod3

-0.09

0.769

Sod3

0.17

0.530

Mn SOD

sod-2

0.43

0.437

Sod2

0.03

0.795

Sod2

-0.03

0.903

Sod2

0.07

0.722

sod-3

4.66

0.000


Log2 FC: log2 of the fold change in mRNA transcript abundance in long-lived relative to normal-lived animals. q, probability that difference in mRNA abundance is the result of chance alone. Instances of significant alteration in gene expression in bold. The predicted sequence of SOD-4 suggests that it may be secreted. EC, extracellular; IC, intracellular.

McElwee et al. Genome Biology 2007 8:R132   doi:10.1186/gb-2007-8-7-r132

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