Table 6 |
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|
Expression of SOD genes in mutant worms, flies, mice with reduced insulin/IGF-1 signaling |
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|
C. elegans |
Drosophila |
Mouse |
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|
|
|
|
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|
Prop-1df/df (Ames) |
Ghrhrlit/lit (Little) |
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|
|
|
|||||||||||
|
Log2 FC |
q |
Log2 FC |
q |
Log2 FC |
q |
Log2 FC |
q |
|||||
|
|
|
|||||||||||
|
Cu/Zn SOD (IC) |
sod-1 |
0.66 |
0.073 |
Sod1 |
0.10 |
0.219 |
Sod1 |
0.01 |
0.957 |
Sod1 |
-0.12 |
0.616 |
|
sod-5 |
2.14 |
0.006 |
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|
Cu/Zn SOD (EC) |
sod-4 |
0.58 |
0.339 |
Sod3 |
-0.09 |
0.769 |
Sod3 |
0.17 |
0.530 |
|||
|
Mn SOD |
sod-2 |
0.43 |
0.437 |
Sod2 |
0.03 |
0.795 |
Sod2 |
-0.03 |
0.903 |
Sod2 |
0.07 |
0.722 |
|
sod-3 |
4.66 |
0.000 |
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|
|
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|
Log2 FC: log2 of the fold change in mRNA transcript abundance in long-lived relative to normal-lived animals. q, probability that difference in mRNA abundance is the result of chance alone. Instances of significant alteration in gene expression in bold. The predicted sequence of SOD-4 suggests that it may be secreted. EC, extracellular; IC, intracellular. |
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|
McElwee et al. Genome Biology 2007 8:R132 doi:10.1186/gb-2007-8-7-r132 |
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