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Strategy for encoding and comparison of gene expression signatures

Yajun Yi1, Chun Li2, Clay Miller1 and Alfred L George13*

Author Affiliations

1 Department of Medicine, Garland Avenue, Vanderbilt University, Nashville, Tennessee 37232-0275,USA

2 Department of Biostatistics, Garland Avenue, Vanderbilt University, Nashville, Tennessee 37232-0275,USA

3 Department of Pharmacology, Garland Avenue, Vanderbilt University, Nashville, Tennessee 37232-0275,USA

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Genome Biology 2007, 8:R133  doi:10.1186/gb-2007-8-7-r133

Published: 5 July 2007

Abstract

EXALT (EXpression signature AnaLysis Tool) is a computational system enabling comparisons of microarray data across experimental platforms and different laboratories http://seq.mc.vanderbilt.edu/exalt/ webcite. An essential feature of EXALT is a database holding thousands of gene expression signatures extracted from the Gene Expression Omnibus, and encoded in a searchable format. This novel approach to performing global comparisons of shared microarray data may have enormous value when coupled directly with a shared data repository.