Strategy for encoding and comparison of gene expression signatures

doi:10.1186/gb-2007-8-7-r133

Genome Biology

Volume 8
Issue 7

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Strategy for encoding and comparison of gene expression signatures

Yajun Yi¹ , Chun Li² , Clay Miller¹ and Alfred L George Jr¹^,3

¹Department of Medicine, Garland Avenue, Vanderbilt University, Nashville, Tennessee 37232-0275,USA

²Department of Biostatistics, Garland Avenue, Vanderbilt University, Nashville, Tennessee 37232-0275,USA

³Department of Pharmacology, Garland Avenue, Vanderbilt University, Nashville, Tennessee 37232-0275,USA

author email corresponding author email

Genome Biology 2007, 8:R133doi:10.1186/gb-2007-8-7-r133


Published:	5 July 2007

Subject areas: Bioinformatics, Genome studies

Abstract

EXALT (EXpression signature AnaLysis Tool) is a computational system enabling comparisons of microarray data across experimental platforms and different laboratories http://seq.mc.vanderbilt.edu/exalt/ webcite. An essential feature of EXALT is a database holding thousands of gene expression signatures extracted from the Gene Expression Omnibus, and encoded in a searchable format. This novel approach to performing global comparisons of shared microarray data may have enormous value when coupled directly with a shared data repository.