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Putative decay components in Plasmodium falciparum were identified using known factors from human and yeast |
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| Components |
Gene |
PlasmoDB ID |
Description |
|
|
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| Deadenylation |
Ccr4 |
PFE0980c† |
Catalytic subunit of the Ccr4/Pop2 deadenylase complex |
| Pop2 |
MAL8P1.104† |
Component of the Ccr4/Pop2 deadenylase complex |
|
| Not1 |
PF11_0049† |
Component of the Ccr4/Not complex |
|
| Not2 |
PF11_0297† |
Component of the Ccr4/Not complex |
|
| Not3 |
? |
Component of the Ccr4/Not complex |
|
| Not4 |
PFL1705w† |
Component of the Ccr4/Not complex |
|
| Not5 |
PF10_0062† |
Component of the Ccr4/Not complex |
|
| Caf130 |
? |
Component of the Ccr4/Not complex |
|
| Caf40 |
PFE0375w |
Component of the Ccr4/Not complex |
|
| PARN |
PF14_0413*† |
Major deadenylase in mammals |
|
| Pab1 |
PFL1170w |
PolyA binding protein |
|
| Pan2 |
? |
Component of the Pan2/Pan3 deadenylase complex |
|
| Pan2 |
? |
Component of the Pan2/Pan3 deadenylase complex |
|
| Decapping |
Dcp1 |
PF10_0314*† |
Component of the Dcp1/Dcp2 decapping complex |
| Dcp2 |
Pf13_0048† |
Catalytic subunit of the Dcp1/Dcp2 decapping complex |
|
| DcpS/Dcs1 |
? |
Scavenger decapping enzyme |
|
| Dhh1 |
PFC0915w |
Helicase-roles in deadenylation and decapping |
|
| Lsm1 |
PF11_0255† |
Involved in decapping |
|
| Lsm2 |
PFE1020w |
Involved in decapping |
|
| Lsm3 |
PF08_0049 |
Involved in decapping |
|
| Lsm4 |
PF11_0524 |
Involved in decapping |
|
| Lsm5 |
PF14_0411 |
Involved in decapping |
|
| Lsm6 |
PF13_0142 |
Involved in decapping |
|
| Lsm7 |
PFL0460w |
Involved in decapping |
|
| Exosome |
Csl4 |
MAL7P1.104 |
Exosome subunit |
| Dis3/Rrp44 |
MAL13P1.289† |
Exosome subunit-RNase II domain |
|
| Mtr3 |
? |
Exosome subunit-RNase PH domain |
|
| Rrp4 |
PFD0515w |
Exosome subunit-hydrolytic exonuclease |
|
| Rrp40 |
MAL13P1.36† |
exosome subunit-hydrolytic exonuclease |
|
| Rrp42 |
MAL13P1.204† |
Exosome subunit-RNase PH domain |
|
| Rrp43 |
? |
Exosome subunit-RNase PH domain |
|
| Rrp45 |
PF13_0340 |
Exosome subunit-RNase PH domain |
|
| Rrp46 |
? |
Exosome subunit-RNase PH domain |
|
| Rrp6 |
PF14_0473 |
Exosome subunit found only in the nucleus |
|
| Ski2 |
PFI0480w |
Helicase associated with the exosome and Ski complex |
|
| Ski3/Ski5 |
? |
Associated with exosome and Ski complex |
|
| Ski6/Rrp41 |
PF14_0256 |
Exosome subunit-RNase PH domain |
|
| Ski7 |
? |
Associated with exosome and Ski complex |
|
| Ski8 |
? |
Associated with exosome and Ski complex |
|
| 5' to 3' decay |
Xrn1 |
PFI0455w/PF11_0074† |
5' to 3' exonuclease-cytoplasmic |
| Rat1 |
PFI0455w/PF11_0074† |
5' to 3' exonuclease-nuclear |
|
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Orthologs were identified using a simple reciprocal best BLASTP match between Plasmodium falciparum and Saccharomyces cerevisiae and between P. falciparum and human sequences. Orthologs could not be found for those genes with question marks. *Components identified only when the human sequence was used for the query sequence. †P. falciparum proteins that either are described in PlasmoDB as hypothetical proteins or, in the case of PF10_0314, are assigned a function other than the one relevant here. | |||
Shock et al. Genome Biology 2007 8:R134 doi:10.1186/gb-2007-8-7-r134 |
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