Genome Biology

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Housekeeping genes tend to show reduced upstream sequence conservation

Domènec Farré1, Nicolás Bellora1,2, Loris Mularoni3, Xavier Messeguer4 and M Mar Albà3,2,5*

Author Affiliations

1 Centre for Genomic Regulation, Dr Aiguader 88, Barcelona 08003, Spain

2 Universitat Pompeu Fabra, Dr Aiguader 88, Barcelona 08003, Spain

3 Fundació Institut Municipal d'Investigació Mèdica, Dr Aiguader 88, Barcelona 08003, Spain

4 Universitat Politècnica de Catalunya, Jordi Girona 1-3, Barcelona 08034, Spain

5 Catalan Institution for Research and Advanced Studies, Pg Lluis Companys 23, Barcelona 08010, Spain

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Genome Biology 2007, 8:R140 doi:10.1186/gb-2007-8-7-r140

Published: 13 July 2007

Additional files

Additional data file 1:

Table S1: human gene sequence divergence values in expression groups according to Gene Atlas (GNF1H). Table S2: human gene sequence divergence values in expression groups according to the eVOC anatomical system classification. Table S3: human gene sequence divergence values in expression groups according to the eVOC cell type classification. Table S4: lists GO terms over-represented and under-represented in HK genes with their average dSM values. Table S5: the organs, tissues, and cell types considered in each expression dataset.

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Additional data file 2:

Expression groups are according to Gene Atlas GNF1H (Figure S1), the eVOC anatomical system classification (Figure S2), and the eVOC cell type classification (Figure S3).

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Additional data file 3:

Complete sequence divergence and expression group data used in this manuscript.

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Additional data file 4:

Human 2 Kb upstream sequences (human promoters), in fasta format.

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Additional data file 5:

Mouse 2 Kb upstream sequences (mouse promoters), in fasta format.

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Open Data