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Housekeeping genes tend to show reduced upstream sequence conservation

Domènec Farré1 email, Nicolás Bellora1,2 email, Loris Mularoni3 email, Xavier Messeguer4 email and M Mar Albà2,3,5 email

1Centre for Genomic Regulation, Dr Aiguader 88, Barcelona 08003, Spain

2Universitat Pompeu Fabra, Dr Aiguader 88, Barcelona 08003, Spain

3Fundació Institut Municipal d'Investigació Mèdica, Dr Aiguader 88, Barcelona 08003, Spain

4Universitat Politècnica de Catalunya, Jordi Girona 1-3, Barcelona 08034, Spain

5Catalan Institution for Research and Advanced Studies, Pg Lluis Companys 23, Barcelona 08010, Spain

author email corresponding author email

Genome Biology 2007, 8:R140doi:10.1186/gb-2007-8-7-r140

Published: 13 July 2007

Subject areas: Evolution, Molecular biology, Bioinformatics


Additional files

Additional data file 1:

Table S1: human gene sequence divergence values in expression groups according to Gene Atlas (GNF1H). Table S2: human gene sequence divergence values in expression groups according to the eVOC anatomical system classification. Table S3: human gene sequence divergence values in expression groups according to the eVOC cell type classification. Table S4: lists GO terms over-represented and under-represented in HK genes with their average dSM values. Table S5: the organs, tissues, and cell types considered in each expression dataset.

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Additional data file 2:

Expression groups are according to Gene Atlas GNF1H (Figure S1), the eVOC anatomical system classification (Figure S2), and the eVOC cell type classification (Figure S3).

Format: PDF Size: 2MB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 3:

Complete sequence divergence and expression group data used in this manuscript.

Format: TXT Size: 587KB Download file

Additional data file 4:

Human 2 Kb upstream sequences (human promoters), in fasta format.

Format: TXT Size: 14MB Download file

Additional data file 5:

Mouse 2 Kb upstream sequences (mouse promoters), in fasta format.

Format: TXT Size: 14MB Download file


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