Housekeeping genes tend to show reduced upstream sequence conservation

Domènec Farré¹ , Nicolás Bellora¹^,2 , Loris Mularoni³ , Xavier Messeguer⁴ and M Mar Albà²^,3^,5

¹Centre for Genomic Regulation, Dr Aiguader 88, Barcelona 08003, Spain

²Universitat Pompeu Fabra, Dr Aiguader 88, Barcelona 08003, Spain

³Fundació Institut Municipal d'Investigació Mèdica, Dr Aiguader 88, Barcelona 08003, Spain

⁴Universitat Politècnica de Catalunya, Jordi Girona 1-3, Barcelona 08034, Spain

⁵Catalan Institution for Research and Advanced Studies, Pg Lluis Companys 23, Barcelona 08010, Spain

author email corresponding author email

Genome Biology 2007, 8:R140doi:10.1186/gb-2007-8-7-r140


Published:	13 July 2007

Subject areas: Evolution, Molecular biology, Bioinformatics

Additional files

Additional data file 1:

Table S1: human gene sequence divergence values in expression groups according to Gene Atlas (GNF1H). Table S2: human gene sequence divergence values in expression groups according to the eVOC anatomical system classification. Table S3: human gene sequence divergence values in expression groups according to the eVOC cell type classification. Table S4: lists GO terms over-represented and under-represented in HK genes with their average d_SMvalues. Table S5: the organs, tissues, and cell types considered in each expression dataset.

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Additional data file 2:

Expression groups are according to Gene Atlas GNF1H (Figure S1), the eVOC anatomical system classification (Figure S2), and the eVOC cell type classification (Figure S3).

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Additional data file 3:

Complete sequence divergence and expression group data used in this manuscript.

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Additional data file 4:

Human 2 Kb upstream sequences (human promoters), in fasta format.

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Additional data file 5:

Mouse 2 Kb upstream sequences (mouse promoters), in fasta format.

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