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Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells

Ke Wei Gong1, Wei Zhao2, Ning Li1, Berenice Barajas1, Michael Kleinman3, Constantinos Sioutas4, Steve Horvath2, Aldons J Lusis1, Andre Nel1* and Jesus A Araujo1

Author Affiliations

1 Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA

2 Departments of Human Genetics and Biostatistics, University of California, Los Angeles, CA 90095, USA

3 Department of Community and Environmental Medicine, University of California, Irvine, CA 92697, USA

4 Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA 90089, USA

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Genome Biology 2007, 8:R149  doi:10.1186/gb-2007-8-7-r149

Published: 26 July 2007

Additional files

Additional data file 1:

The number of genes that DEP and ox-PAPC significantly downregulate.

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Open Data

Additional data file 2:

Heat map of the yellow module, where a pattern of synergistic/additive interaction is noted.

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Open Data

Additional data file 3:

Selected pathway analysis on the total number of genes that were significantly regulated by DEP and/or ox-PAPC.

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Additional data file 4:

The distribution of genes for particular pathways in the gene coexpression network modules.

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Additional data file 5:

A list of genes that exhibited a synergistic mode of regulation in the gene network.

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Open Data

Additional data file 6:

SIs of representative genes as determined from microarray and qPCR data.

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Open Data

Additional data file 7:

The recovery of major organic fractions from 1 g DEP.

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Additional data file 8:

The content of polycyclic aromatic hydrocarbons in crude DEP extract and fractions.

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Additional data file 9:

The quinone content in crude DEP extract and fractions.

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Open Data