Research
Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells
1 Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
2 Departments of Human Genetics and Biostatistics, University of California, Los Angeles, CA 90095, USA
3 Department of Community and Environmental Medicine, University of California, Irvine, CA 92697, USA
4 Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA 90089, USA
Genome Biology 2007, 8:R149 doi:10.1186/gb-2007-8-7-r149
Published: 26 July 2007Additional files
Additional data file 1:
The number of genes that DEP and ox-PAPC significantly downregulate.
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Additional data file 2:
Heat map of the yellow module, where a pattern of synergistic/additive interaction is noted.
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Additional data file 3:
Selected pathway analysis on the total number of genes that were significantly regulated by DEP and/or ox-PAPC.
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Additional data file 4:
The distribution of genes for particular pathways in the gene coexpression network modules.
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Additional data file 5:
A list of genes that exhibited a synergistic mode of regulation in the gene network.
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Additional data file 6:
SIs of representative genes as determined from microarray and qPCR data.
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Additional data file 7:
The recovery of major organic fractions from 1 g DEP.
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Additional data file 8:
The content of polycyclic aromatic hydrocarbons in crude DEP extract and fractions.
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Additional data file 9:
The quinone content in crude DEP extract and fractions.
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