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Gong KW
Zhao W
Li N
Barajas B
Kleinman M
Sioutas C
Horvath S
Lusis AJ
Nel A
Araujo JA

on PubMed

Gong KW
Zhao W
Li N
Barajas B
Kleinman M
Sioutas C
Horvath S
Lusis AJ
Nel A
Araujo JA
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Research

Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells

Ke Wei Gong¹ , Wei Zhao² , Ning Li¹ , Berenice Barajas¹ , Michael Kleinman³ , Constantinos Sioutas⁴ , Steve Horvath² , Aldons J Lusis¹ , Andre Nel¹ and Jesus A Araujo¹

¹Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA

²Departments of Human Genetics and Biostatistics, University of California, Los Angeles, CA 90095, USA

³Department of Community and Environmental Medicine, University of California, Irvine, CA 92697, USA

⁴Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA 90089, USA

author email corresponding author email

Genome Biology 2007, 8:R149doi:10.1186/gb-2007-8-7-r149


Published:	26 July 2007

Subject areas: Physiology, Genome studies, Medicine

Additional files

Additional data file 1:

The number of genes that DEP and ox-PAPC significantly downregulate.

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Additional data file 2:

Heat map of the yellow module, where a pattern of synergistic/additive interaction is noted.

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Additional data file 3:

Selected pathway analysis on the total number of genes that were significantly regulated by DEP and/or ox-PAPC.

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Additional data file 4:

The distribution of genes for particular pathways in the gene coexpression network modules.

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Additional data file 5:

A list of genes that exhibited a synergistic mode of regulation in the gene network.

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Additional data file 6:

SIs of representative genes as determined from microarray and qPCR data.

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Additional data file 7:

The recovery of major organic fractions from 1 g DEP.

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Additional data file 8:

The content of polycyclic aromatic hydrocarbons in crude DEP extract and fractions.

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Additional data file 9:

The quinone content in crude DEP extract and fractions.

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