Impacts of yeast metabolic network structure on enzyme evolution

Chenqi Lu¹, Ze Zhang², Lindsey Leach³, MJ Kearsey³ and ZW Luo¹^,3

¹Laboratory of Population and Quantitative Genetics, School of Life Sciences, Institute of Biostatistics, Fudan University, Shanghai 200433, China

²The Key Sericultural Laboratory of the Agricultural Ministry, Southwest University, Chongqing 400716, China

³School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

author email corresponding author email

Genome Biology 2007, 8:407doi:10.1186/gb-2007-8-8-407


Published:	9 August 2007

Subject areas: Genome studies, Evolution, Bioinformatics, Biochemistry and structural biology

Additional data file 1:

Materials and methods for the analyses carried out.

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Additional data file 2:

The method for the creation of a directed enzyme network from a metabolic network that was used in this study.

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Additional data file 3:

Original data of network and evolutionary parameters for 580 enzymatic genes in the yeast network.

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Additional data file 4:

The correlation between enzyme connectivity and betweenness in (a) the yeast metabolic network and (b) a random scale-free network.

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Additional data file 5:

The relationship between Ka/Ks and both (a) the betweenness and (b) the connectivity.

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