Table 3

Classification of ER+ intrinsic subtypes, medullary breast cancer, and BRCA1 tumors into ER- subclasses

ER+

MBC

DBC

BRCA1


Luminal B

Luminal A

Normal

Basal

HER2


n

97

337

32

19

42

22

44

18

n classifiable

37

113

19

17

16

20

33

16

CC+/IR+

17

2

0

13

11

14

4

13

CC+

20

2

0

4

1

3

3

2

ECM+

0

71

16

0

0

1

3

1

SR+

0

9

0

0

0

0

20

0

IR+

0

29

3

0

4

2

3

0


Classification of ER+ intrinsic subtypes (527 samples from the integrated cohort NKI2 + EMC + NCH), 22 medullary breast cancers (MBCs) and 44 ductal breast cancers (DBCs) from [38], and 18 BRCA1 mutants from [3] into ER- subclasses, using the nearest centroid criterion with Pearson correlation as distance metric. Only samples with Pearson correlation coefficients larger than 0.25 were deemed classifiable. ER, estrogen receptor.

Teschendorff et al. Genome Biology 2007 8:R157   doi:10.1186/gb-2007-8-8-r157

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