Table 4 |
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|
Univariate and Multivariate Cox-regression model |
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|
ER- (n = 186) |
ER+ (n = 527) |
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|
|
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|
HR (95% CI) |
P |
HR (95% CI) |
P |
|
|
|
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|
LN |
2.28 (1.36-3.85) |
0.002 |
2.07 (1.47-2.90) |
<10-4 |
|
LI |
1.06 (0.66-1.70) |
0.9 |
1.50 (0.72-3.14) |
0.58 |
|
IRM |
2.02 (1.19-3.41) |
0.009 |
1.25 (0.91-1.71) |
0.19 |
|
LNa + IRM |
2.16 (1.28-3.64) |
0.004 |
2.10 (1.49-2.96) |
<10-4 |
|
LN + IRMa |
1.93 (1.14-3.26) |
0.015 |
1.29 (0.94-1.76) |
0.11 |
|
LIa + IRM |
0.86 (0.32-2.28) |
0.76 |
1.75 (0.41-7.47) |
0.45 |
|
LI + IRMa |
2.05 (0.71-5.97) |
0.19 |
0.57 (0.27-1.19) |
0.13 |
|
LNa + LI + IRM |
1.79 (0.70-4.62) |
0.22 |
1.48 (0.68-3.19) |
0.32 |
|
LN + LIa + IRM |
0.84 (0.51-1.38) |
0.72 |
1.65 (0.38-7.07) |
0.5 |
|
LN + LI + IRMa |
2.22 (0.76-6.50) |
0.15 |
0.57 (0.27-1.20) |
0.14 |
|
|
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|
The table summarizes the hazard ratio (HR), 95% confidence interval (CI), and log-rank test P values of univariate Cox proportional hazards regression models, with lymph node status (LN = 1/0 for LN +/-), level of lymphocytic infiltration (LI = 1 for low infiltration score, and LI = 0 for high infiltration score) and the classification based on the seven-gene immune response related module (IRM; 2 = down-regulation of module, 1 = upregulation of module) as predictors. aCorresponding values in the multivariate Cox models including LN, LI, and IR module as predictors. The table compares the values for estrogen receptor (ER)- and ER+ breast cancer. |
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|
Teschendorff et al. Genome Biology 2007 8:R157 doi:10.1186/gb-2007-8-8-r157 |
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