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The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression

Lawrence S Hon and Zemin Zhang*

Author Affiliations

Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA

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Genome Biology 2007, 8:R166  doi:10.1186/gb-2007-8-8-r166

Published: 14 August 2007

Additional files

Additional data file 1:

Different analyses performed using the relative expression metric.

Format: PDF Size: 12KB Download file

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Open Data

Additional data file 2:

Figures using alternative data sets that support the observed trends.

Format: PDF Size: 7KB Download file

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Additional data file 3:

Description of the tables of the raw relative expression data and associated data found in Additional data files 4-8.

Format: PDF Size: 4KB Download file

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Open Data

Additional data file 4:

Relative expression values for all PicTar predicted interactions using the Lu/Ramaswamy set of expression data.

Format: TAB Size: 1.7MB Download file

Open Data

Additional data file 5:

Relative expression values for all PicTar predicted interactions using the NCI-60 set of expression data.

Format: TAB Size: 2.9MB Download file

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Additional data file 6:

Relative expression values for all rna22 predicted interactions using the Lu/Ramaswamy set of expression data.

Format: TAB Size: 1.9MB Download file

Open Data

Additional data file 7:

Relative expression values for specific pairs of binding sites (<1000 bp apart) responsive to a miRNA, using Lu/Ramaswamy data and PicTar predictions.

Format: TAB Size: 1.6MB Download file

Open Data

Additional data file 8:

Relative expression values for specific pairs of binding sites (<1000 bp apart) responsive to a miRNA, using NCI-60 data and PicTar predictions.

Format: TAB Size: 2.7MB Download file

Open Data