Genome Biology

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Open Access Research

The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever

Kathleen H Rubins1,2,3*, Lisa E Hensley4, Victoria Wahl-Jensen4, Kathleen M Daddario DiCaprio4, Howard A Young5, Douglas S Reed4, Peter B Jahrling4, Patrick O Brown2,6, David A Relman1,7,8 and Thomas W Geisbert4

Author Affiliations

1 Department of Microbiology and Immunology, 299 Campus Dr., Stanford University School of Medicine, Stanford, California 94305, USA

2 Department of Biochemistry, 279 Campus Dr., Stanford University School of Medicine, Stanford, California 94305, USA

3 Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA

4 US Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Maryland 21702-5011, USA

5 National Cancer Institute - Frederick, 1050 Boyles St., Frederick, Maryland 21702, USA

6 Howard Hughes Medical Institute, 279 Campus Dr., Stanford University School of Medicine, Stanford, California 94305, USA

7 Department of Medicine, 300 Pasteur Dr., Stanford University School of Medicine, Stanford, California 94305, USA

8 Veterans Affairs Palo Alto Health Care System, 3801 Miranda Ave., Palo Alto, California 94304, USA

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Genome Biology 2007, 8:R174 doi:10.1186/gb-2007-8-8-r174

Published: 28 August 2007

Additional files

Additional data file 1:

Animal tattoo number for each blood sample listed by Day. Gene expression profiles in all figures are arranged from left to right for each day post-infection, as listed in the table.

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Open Data

Additional data file 2:

Each bleed day for each animal is indicated with an X. Serial samples for all animals on all days were not taken, due to Laboratory Animal care and Use Committee restrictions on maximum blood volume amounts.

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Open Data

Additional data file 3:

Correlation coefficients were calculated between the expression pattern of each gene and each clinical parameter. The correlation coefficients are plotted as moving averages of 41 genes.

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Open Data