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The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever

Kathleen H Rubins1,2,3 email, Lisa E Hensley4 email, Victoria Wahl-Jensen4 email, Kathleen M Daddario DiCaprio4 email, Howard A Young5 email, Douglas S Reed4 email, Peter B Jahrling4 email, Patrick O Brown2,6 email, David A Relman1,7,8 email and Thomas W Geisbert4 email

1Department of Microbiology and Immunology, 299 Campus Dr., Stanford University School of Medicine, Stanford, California 94305, USA

2Department of Biochemistry, 279 Campus Dr., Stanford University School of Medicine, Stanford, California 94305, USA

3Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA

4US Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Maryland 21702-5011, USA

5National Cancer Institute - Frederick, 1050 Boyles St., Frederick, Maryland 21702, USA

6Howard Hughes Medical Institute, 279 Campus Dr., Stanford University School of Medicine, Stanford, California 94305, USA

7Department of Medicine, 300 Pasteur Dr., Stanford University School of Medicine, Stanford, California 94305, USA

8Veterans Affairs Palo Alto Health Care System, 3801 Miranda Ave., Palo Alto, California 94304, USA

author email corresponding author email

Genome Biology 2007, 8:R174doi:10.1186/gb-2007-8-8-r174

Published: 28 August 2007

Subject areas: Genome studies, Immunology, Model organisms


Additional files

Additional data file 1:

Animal tattoo number for each blood sample listed by Day. Gene expression profiles in all figures are arranged from left to right for each day post-infection, as listed in the table.

Format: PDF Size: 9KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 2:

Each bleed day for each animal is indicated with an X. Serial samples for all animals on all days were not taken, due to Laboratory Animal care and Use Committee restrictions on maximum blood volume amounts.

Format: PDF Size: 8KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 3:

Correlation coefficients were calculated between the expression pattern of each gene and each clinical parameter. The correlation coefficients are plotted as moving averages of 41 genes.

Format: PDF Size: 90KB Download file

This file can be viewed with: Adobe Acrobat Reader


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