Figure 8.

Preclinical gene expression. (a) Genes with transcripts whose abundance shows at least a twofold increase or decrease from baseline (day 0) in at least three of the samples for day 1 or day 2 are shown. The expression patterns of 317 elements (202 unique named genes) were hierarchically clustered; rows represent individual genes and columns represent samples. These patterns reflect changes in gene expression before symptoms appear. (b) Virus isolation from plasma. Infectious virus in EDTA plasma was assayed by counting plaqueson Vero cells maintained as monolayers in six-well plates under agarose, as previously described [70].