Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery

Hong-Fang Ji , De-Xin Kong , Liang Shen , Ling-Ling Chen , Bin-Guang Ma and Hong-Yu Zhang

Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China

author email corresponding author email

Genome Biology 2007, 8:R176doi:10.1186/gb-2007-8-8-r176


Published:	29 August 2007

Subject areas: Bioinformatics, Evolution, Biochemistry and structural biology

Additional files

Additional data file 1:

Ligands and the numbers of domains and folds that bind them.

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Additional data file 2:

Power-law behaviors of metabolism-relevant ligands.

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Additional data file 3:

Building blocks and ownerships of metabolism-relevant ligands.

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Additional data file 4:

Power-law behaviors of folds for proteins binding ATP, ADP and NAD.

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Additional data file 5:

Building block usage of bio-ligands.

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