Table 3

The most prevalent bio-ligands in the fold universe (shared by 15+ folds) and the most common folds used by host proteins of each ligand

Ligands

Number of folds

Most common folds

Adenosine-5'-triphosphate (ATP)

35

P-loop containing nucleoside triphosphate hydrolases (c.37)

Adenosine-5'-diphosphate (ADP)

31

P-loop containing nucleoside triphosphate hydrolases (c.37)

Guanosine-5'-diphosphate (GDP)

29

P-loop containing nucleoside triphosphate hydrolases (c.37)

Nicotinamide-adenine-dinucleotide (NAD)

27

NAD(P)-binding Rossmann-fold domains (c.2)

Flavin-adenine dinucleotide (FAD)

21

FAD/NAD(P)-binding domain (c.3)

Dihydro-nicotinamide-adenine-dinucleotide phosphate (NDP)

18

NAD(P)-binding Rossmann-fold domains (c.2)

Nicotinamide-adenine-dinucleotide phosphate (NAP)

16

NAD(P)-binding Rossmann-fold domains (c.2)

Flavin mononucleotide (FMN)

16

Flavodoxin-like (c.23)

Adenosine monophosphate (AMP)

15

Adenine nucleotide alpha hydrolase-like (c.26)

Ji et al. Genome Biology 2007 8:R176   doi:10.1186/gb-2007-8-8-r176