ChIP-chip. Regions of interest on DNA are densely tiled, with probes separated by short distances. In this figure, each bar corresponds to the log-ratio hybridization signals of two channels measured by a probe. Small sub-regions that are over-represented compared to the genomic background will appear as pronounced peaks (in this example, the middle peak represents the DNA fragments containing a protein-binding site). The computational challenge is to normalize the data properly and to detect confident enriched regions by filtering out false peaks (left and right peaks in this example).
Song et al. Genome Biology 2007 8:R178 doi:10.1186/gb-2007-8-8-r178