|
Comparison of MA2C with other algorithms using a spike-in experiment with a total of 96 regions and 47 unique non-overlapping regions |
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| Algorithm |
CHIP_ID |
PPV |
Sensitivity |
Unique |
Correlation |
|
|
|||||
| ChIPOTle |
49875 |
71% |
85% |
40 |
0.72 |
| 49880 |
69% |
98% |
47 |
0.76 |
|
| 49883 |
73% |
98% |
47 |
0.79 |
|
| MPeak |
49875 |
100% |
91% |
46 |
0.74 |
| 49880 |
96% |
89% |
46 |
0.71 |
|
| 49883 |
98% |
89% |
46 |
0.79 |
|
| MA2C |
49875 |
99% |
91% |
47 |
0.78 |
| (C = 2 normalized) |
49880 |
96% |
94% |
47 |
0.79 |
| 49883 |
99% |
95% |
47 |
0.81 |
|
| All 3 |
96% |
96% |
47 |
0.81 |
|
| MA2C |
49875 |
99% |
92% |
46 |
0.77 |
| (Global median-scaled) |
49880 |
100% |
93% |
46 |
0.79 |
| 49883 |
99% |
92% |
46 |
0.81 |
|
| All 3 |
100% |
95% |
47 |
0.80 |
|
|
PPV (positive predictive value) = no. of true positive peaks/no. of total peaks. Sensitivity = no. of detected true positive regions/96. Unique = number of unique regions found. Correlation = correlation coefficient of the spike-in log fold-changes and algorithm-assigned scores for the 47 unique regions. | |||||
Song et al. Genome Biology 2007 8:R178 doi:10.1186/gb-2007-8-8-r178 |
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