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Dynamic cumulative activity of transcription factors as a mechanism of quantitative gene regulation

Feng He1, Jan Buer23, An-Ping Zeng45 and Rudi Balling1*

Author Affiliations

1 Biological Systems Analysis Group, HZI- Helmholtz Centre for Infection Research, Inhoffenstrasse, D-38124 Braunschweig, Germany

2 Mucosal Immunity Group, HZI- Helmholtz Centre for Infection Research, Inhoffenstrasse, D-38124 Braunschweig, Germany

3 Institute of Medical Microbiology, Hannover Medical School (MHH), D-30625 Hannover, Germany

4 Systems Biology Group, HZI- Helmholtz Centre for Infection Research, Inhoffenstrasse, D-38124 Braunschweig, Germany

5 Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickerstrasse, D-21073 Hamburg, Germany

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Genome Biology 2007, 8:R181  doi:10.1186/gb-2007-8-9-r181

Published: 4 September 2007

Additional files

Additional data file 1:

Detailed results of all the two-regulator motifs in the Cho data and the distribution of the time-shift and conversion efficiencies of given regulators among different convergence modes.

Format: XLS Size: 222KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional data file 2:

Detailed results of all the three-regulator motifs in the Cho data.

Format: XLS Size: 75KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional data file 3:

Detailed results of all the two-regulator motifs in the Spellman data and comparison with the results from the Cho data.

Format: XLS Size: 97KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional data file 4:

Detailed results of all the three-regulator motifs in the Spellman data and comparison with the results from the Cho data.

Format: XLS Size: 48KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional data file 5:

Detailed results of all the two- and three-regulator motifs in the glucose pulse perturbation data.

Format: XLS Size: 204KB Download file

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Open Data

Additional data file 6:

Detailed results of all the two- and three-regulator motifs in the H2O2 stress data.

Format: XLS Size: 164KB Download file

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Open Data

Additional data file 7:

Summary and references for genes in the present work involved in the cell-cycle process as annotated by the Gene Ontology database.

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Additional data file 8:

Results for convergence modes from the randomized expression data with 17 time points, for random networks, and details of FDRs, as well as the number of combinations in all the cases listed in Table 1, and the P value distribution figures for time-series datasets with 17 time points and 5 time points.

Format: DOC Size: 140KB Download file

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Open Data