Shifted cumulative regulation. Illustration of the concept that transcription expression profiles (non-normalized) of regulator YML027W (YOX1, red line) and regulator YMR016C (SOK2, blue line) are dynamically combined. This demonstrates a significant match between the combinatorial expression profile and the expression of the target gene YOR039W (CKB2) in the studied dataset. The conversion efficiency, which indicates the ratio between the number of functional activated binding regulators and the number of available transcription factor transcripts, is presented as a percentage (10% and 70% here).
He et al. Genome Biology 2007 8:R181 doi:10.1186/gb-2007-8-9-r181