Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Open Access Highly Accessed Software

The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists

Da Wei Huang1, Brad T Sherman1, Qina Tan1, Jack R Collins2, W Gregory Alvord3, Jean Roayaei3, Robert Stephens2, Michael W Baseler4, H Clifford Lane5 and Richard A Lempicki1*

Author Affiliations

1 Laboratory of Immunopathogenesis and Bioinformatics, Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA

2 Advanced Biomedical Computing Center, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA

3 Computer and Statistical Services, Data Management Services, National Cancer Institute at Frederick, Frederick, MD 21702, USA

4 Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA

5 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

For all author emails, please log on.

Genome Biology 2007, 8:R183  doi:10.1186/gb-2007-8-9-r183

Published: 4 September 2007

Abstract

The DAVID Gene Functional Classification Tool http://david.abcc.ncifcrf.gov webcite uses a novel agglomeration algorithm to condense a list of genes or associated biological terms into organized classes of related genes or biology, called biological modules. This organization is accomplished by mining the complex biological co-occurrences found in multiple sources of functional annotation. It is a powerful method to group functionally related genes and terms into a manageable number of biological modules for efficient interpretation of gene lists in a network context.