Table 6

Functional annotations (GO, KEGG, Biocarta) enriched in transcripts downregulated* in BMP2+ cells compared to control cells in seven-day-old EBs and to undifferentiated BMP2 ES cells

Category

Term

Count

p value


GOTERM_BP_5

DNA metabolism

15

8.4E-5

GOTERM_BP_5

M phase of mitotic cell cycle

7

5.2E-4

GOTERM_BP_5

Carboxylic acid metabolism

11

2.8E-3

GOTERM_CC_5

Chromosome

9

3.8E-3

GOTERM_BP_5

Biopolymer modification

22

9.4E-3

GOTERM_MF_5

Pyrophosphatase activity

10

9.5E-3

GOTERM_BP_5

Amino acid metabolism

6

3.2E-2

GOTERM_BP_5

Recombinational repair

2

3.9E-2

GOTERM_BP_5

Cellular protein metabolism

31

4.2E-2

GOTERM_CC_5

Heterotrimeric G-protein complex

3

4.3E-2

GOTERM_MF_5

Metalloendopeptidase activity

4

5.0E-2

GOTERM_CC_5

Chromosome, periventric region

3

5.9E-2

GOTERM_CC_5

Condensed chromosome

3

6.4E-2

GOTERM_BP_5

Lipid biosynthesis

5

7.5E-2

KEGG_PATHWAY

Pyruvate metabolism

3

7.7E-2

GOTERM_BP_5

Steroid biosynthesis

3

8.3E-2

GOTERM_BP_5

Double-strand break repair

2

8.4E-2

GOTERM_BP_5

Regulation of smooth muscle contraction

2

8.4E-2

GOTERM_MF_5

Phosphoric hydrolase activity

3

9.4E-2

GOTERM_MF_5

AMP binding

2

9.7E-2


*Fold change >2, Student's t-test p value < 0.01. Count indicates the number of genes in the functional annotation category. The p value is from gene enrichment in annotation terms calculated by the Fisher's exact t-test.

Doss et al. Genome Biology 2007 8:R184   doi:10.1186/gb-2007-8-9-r184

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