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Cross-species cluster co-conservation: a new method for generating protein interaction networks

Anis Karimpour-Fard1, Corrella S Detweiler2, Kimberly D Erickson2, Lawrence Hunter1 and Ryan T Gill3*

Author Affiliations

1 Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA

2 MCD-Biology, University of Colorado, Boulder, CO 80309, USA

3 Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, USA

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Genome Biology 2007, 8:R185  doi:10.1186/gb-2007-8-9-r185

Published: 5 September 2007

Additional files

Additional data file 1:

Comparison of TIGR functional categories of predicted pairs at three different confidence levels. The first method (1) used only E. coli K12. Each subsequent method added an additional (underlined) bacterial strain. 1, E. coli K12; 2, E. coli K12 and

    E. coli O157
; 3, E. coli K12, E. coli O157 and
    S. flexneri
; 4, E. coli K12, E. coli O157, S. flexneri, and
    S. typhimurium LT2
; 5, E. coli K12, E. coli O157, S. flexneri, S. typhimurium LT2, and
    P. aeruginosa
; 6, E. coli K12, E. coli O157, S. flexneri, S. typhimurium LT2, P. aeruginosa, and
    B. subtilis
. Same functional category (blue); different functional category (green); at least one protein is unclassified (yellow).

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Open Data