Using CS-CCC to assign protein function. (a) Co-conservation of GGDEF and EAL domains across E. coli K12 (green edge) and P. aeruginosa (mustard edge). Proteins are color coded based on function: motility regulators, orange; sensors, red; RNase II modulators, yellow; two-component response regulators, light blue; diguanylate cyclases, blue; phosphodiesterases, purple; uncategorized, gray. (b) Co-conservation of triplet YcgB, YeaH, and YeaG across several species. Edge color code: E. coli K12, green; E. coli O157, blue; Shigella flexneri, black; S. typhimurium LT2, purple; P. aeruginosa, mustard.
Karimpour-Fard et al. Genome Biology 2007 8:R185 doi:10.1186/gb-2007-8-9-r185