Figure 3.

Two-sided binomial test on the data from Krogan and coworkers [11]. The scatter-plot shows (op,ip) for each p ∈ VBP from the report by Krogan and coworkers [11] (axes are scaled by the square root). The proteins that fall outside of the diagonal band exhibit high asymmetry in unreciprocated degree. This figure shows a graphical representation of a two-sided binomial test. The points above and below the diagonal band are proteins for which we reject the null hypothesis that the distribution of unreciprocated edges is governed by B(np,<a onClick="popup('http://genomebiology.com/2007/8/9/R186/mathml/M1','MathML',630,470);return false;" target="_blank" href="http://genomebiology.com/2007/8/9/R186/mathml/M1">View MathML</a>). For the purpose of visualization, small random offsets were added to the discrete coordinates of the data points by the R function jitter. VBP, viable bait/prey.

Chiang et al. Genome Biology 2007 8:R186   doi:10.1186/gb-2007-8-9-r186
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