Matrix representation on two separate bait to prey datasets. A schematic representation of the interactome coverage of two protein interaction experiments. The adjacency matrix of the complete interactome is represented by the large square. Experiment 1 covers a certain set of proteins as baits (rows covered by the green vertical line) and as prey (columns covered by the green horizontal line). The tested interactions for experiment 1 are contained within the green rectangle. Similarly, experiment 2 covers another set of proteins and tests for a set of interactions contained in the purple rectangle. In the intersection of the rectangles, the red area, are the bait to prey interactions tested by both experiments, and in the union are the interactions tested by at least one of the experiments. Note that the interactions in the light gray area were tested by neither experiment, either because there are missing tested prey (upper right corner) or missing tested baits (lower left corner). The interactions in the white region are also tested by neither experiment because both the baits and the prey were not tested.
Chiang et al. Genome Biology 2007 8:R186 doi:10.1186/gb-2007-8-9-r186