Table 1

Top 20 LeFE Categories for current versus never-smokers classification

Rank
Category
FDR

1
Electron transporter activity BioCarta
~0
1
Carbohydrate metabolism (GO:0005975)
~0
1
Electron transport BioCarta
~0
1
Glutathione metabolism GenMAPP
~0
1
Pentose Phosphate Pathway BLACK
~0
6
Xenobiotic metabolism (GO:0006805)
0.016
6
O Glycans biosynthesis GenMAPP
0.016
8
PentosePathway BLACK
0.045
9
Protein amino acid O-linked glycosylation (GO:0006493)
0.069
10
Pentose phosphate pathway GenMAPP
0.094
10
Gamma hexachlorocyclohexane degradation GenMAPP
0.094
12
Tyrosine metabolism GenMAPP
0.097
13
Cysteine metabolism (GO:0006534)
0.105
13
G1pPathway BLACK
0.105
13
T cell differentiation (GO:0030217)
0.105
13
Fatty acid metabolism BioCarta
0.105
17
Retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)
0.11
18
Aldehyde metabolism (GO:0006081)
0.11
19
Digestion (GO:0007586)
0.114
19
MAP00051 Fructose and mannose metabolism GenMAPP
0.114

FDR, false discovery rate; GO, Gene Ontology; LeFE, Learner of Functional Enrichment.

Eichler et al. Genome Biology 2007 8:R187   doi:10.1186/gb-2007-8-9-r187