Table 3

Top 20 categories for sensitivity to gefitinib

Rank

Category

FDR


1

Androgen up genes na

0.347

2

EGF receptor signaling pathway BioCarta

0.408

3

MAP00100 Sterol biosynthesis GenMAPP

0.531

4

Epidermal growth factor receptor signaling pathway (GO:0007173)

0.531

5

G1/S transition of mitotic cell cycle (GO:0000082)

0.628

6

positive regulation of I-kappaB kinase/NF-kappaB cascade (GO:0043123)

0.628

7

Cell-cell adhesion (GO:0016337)

0.748

8

Aspartate catabolism (GO:0006533)

0.915

9

Calcium-independent cell-cell adhesion (GO:0016338)

0.915

10

Regulation of glycolysis (GO:0006110)

0.915

11

Detection of pest, pathogen or parasite (GO:0009596)

0.915

12

MalatePathway BLACK

0.915

12

RarPathway BLACK

0.915

14

Epidermis development (GO:0008544)

0.931

14

Regulation of endocytosis (GO:0030100)

0.931

16

NFKB reduced Hinata et al 2003

0.998

17

mRNA editing (GO:0006381)

~1

17

EMT DOWN Jechlinger et al 2003

~1

19

Chloride transport (GO:0006821)

~1

19

Induction of apoptosis by intracellular signals (GO:0008629)

~1


FDR, false discovery rate; GO, Gene Ontology; LeFE, Learner of Functional Enrichment.

Eichler et al. Genome Biology 2007 8:R187   doi:10.1186/gb-2007-8-9-r187

Open Data