Table 3 |
||
|
Top 20 categories for sensitivity to gefitinib |
||
|
Rank |
Category |
FDR |
|
|
||
|
1 |
Androgen up genes na |
0.347 |
|
2 |
EGF receptor signaling pathway BioCarta |
0.408 |
|
3 |
MAP00100 Sterol biosynthesis GenMAPP |
0.531 |
|
4 |
Epidermal growth factor receptor signaling pathway (GO:0007173) |
0.531 |
|
5 |
G1/S transition of mitotic cell cycle (GO:0000082) |
0.628 |
|
6 |
positive regulation of I-kappaB kinase/NF-kappaB cascade (GO:0043123) |
0.628 |
|
7 |
Cell-cell adhesion (GO:0016337) |
0.748 |
|
8 |
Aspartate catabolism (GO:0006533) |
0.915 |
|
9 |
Calcium-independent cell-cell adhesion (GO:0016338) |
0.915 |
|
10 |
Regulation of glycolysis (GO:0006110) |
0.915 |
|
11 |
Detection of pest, pathogen or parasite (GO:0009596) |
0.915 |
|
12 |
MalatePathway BLACK |
0.915 |
|
12 |
RarPathway BLACK |
0.915 |
|
14 |
Epidermis development (GO:0008544) |
0.931 |
|
14 |
Regulation of endocytosis (GO:0030100) |
0.931 |
|
16 |
NFKB reduced Hinata et al 2003 |
0.998 |
|
17 |
mRNA editing (GO:0006381) |
~1 |
|
17 |
EMT DOWN Jechlinger et al 2003 |
~1 |
|
19 |
Chloride transport (GO:0006821) |
~1 |
|
19 |
Induction of apoptosis by intracellular signals (GO:0008629) |
~1 |
|
|
||
|
FDR, false discovery rate; GO, Gene Ontology; LeFE, Learner of Functional Enrichment. |
||
|
Eichler et al. Genome Biology 2007 8:R187 doi:10.1186/gb-2007-8-9-r187 |
||
