Table 1

Gene families enriched in muscle cells

Cosmid Name

Common Name

Rank M0

Rank M24

KOG (or other description)


Muscle

K12F2.1

myo-3

710

240

Myosin class II heavy chain

structure and function

F11C3.3

unc-54

-

431

Myosin class II heavy chain

Y11D7A.14

-

826

Myosin class II heavy chain

F45G2.2

-

743

Myosin class II heavy chain

C36E6.3

mlc-1

93

156

Myosin regulatory light chain, EF-Hand protein superfamily

C36E6.5

mlc-2

329

189

Myosin regulatory light chain, EF-Hand protein superfamily

F09F7.2

mlc-3

279

246

Myosin essential light chain, EF-Hand protein superfamily

F07A5.7

unc-15

18

298

Myosin class II heavy chain

ZK617.1

unc-22

493

245

Projectin/twitchin and related proteins

W06H8.8

ttn-1

168

534

Projectin/twitchin and related proteins

F54E2.3

ketn-1

6

154

Unnamed Protein (Invertebrate Titin-like protein)

K03E6.6

pfn-3

64

94

Profilin

K06A4.3

584

389

Actin regulatory proteins (gelsolin/villin family)

Y71G12B.11

4

122

Talin

W03F11.6

afd-1

-

393

Actin filament-binding protein Afadin

F08A8.6

tag-138

-

474

Actin-binding protein SLA2/Huntingtin-interacting protein Hip1

Y66H1B.3

462

784

Actin-binding cytoskeleton protein, filamin

Y66H1B.2

119

902

Actin-binding cytoskeleton protein, filamin

R01H10.3

cor-1

766

20

Actin-binding protein Coronin, contains WD40 repeats

Y105E8B.1

lev-11

530

508

Actin filament-coating protein tropomyosin

F42E11.4

tni-1

120

215

Troponin I

ZK721.2

unc-27

236

111

Troponin I

T20B3.2

tni-3

311

235

Troponin I

T22E5.5

mup-2

230

166

Troponin

C14F5.3

tnt-3

173

281

Troponin

ZC477.9

deb-1

13

271

Alpha-catenin

ZK1058.2

pat-3

99

-

Integrin beta subunit (N-terminal portion of extracellular region)

C29F9.7

pat-4

428

401

Integrin-linked kinase

F54C1.7

pat-10

184

53

Calmodulin and related proteins (EF-Hand superfamily)

C47E8.7

unc-112

436

559

Mitogen inducible gene product (contains ERM and PH domains)

C18A11.7

dim-1

108

74

Immunoglobin and related proteins

K11C4.5

unc-68

438

318

(Ryanodine receptor, Ca2+ release channel)

K11D9.2

sca-1

192

31

Ca2+ transporting ATPase

C18E9.1

cal-2

470

547

Calmodulin and related proteins (EF-Hand superfamily)

C54E10.2

-

578

Ca2+ sensor (EF-Hand superfamily)

F21A10.1

760

650

Ca2+ sensor (EF-Hand superfamily)

K03E6.3

ncs-3

659

185

Ca2+ sensor (EF-Hand superfamily)

F40E10.3

csq-1

157

234

Calsequestrin

Dystrophin glycoprotein complex

F15D3.1

dys-1

265

869

Dystrophin-like protein

C33G3.1

dyc-1

187

774

Muscular protein implicated in muscular dystrophy phenotype

F30A10.8

stn-1

626

476

Syntrophins (type beta)

F07H5.2

sgn-1

275

121

Gamma/delta sarcoglycan

K01A2.1

sgcb-1

210

640

(Beta-sarcoglycan)

H22K11.4

415

35

Sarcoglycan complex, alpha/epsilon subunits

F27D9.8

stn-2

92

-

Syntrophin (type gamma)

T03F7.1

snf-11

507

644

(Sodium-neurotransmitter symporter)

Transcription factors

Y47D3B.7

sbp-1

326

7

Predicted DNA-binding protein

F46G10.6

mxl-3

556

8

Upstream transcription factor 2/L-myc-2 protein

T20B3.3

srh-215

-

52

Predicted olfactory G-protein coupled receptor

T26C11.1

tbx-41

-

127

TBX2 and related T-box transcription factors

T04C10.4

atf-5

-

175

Activating transcription factor 4

C29G2.5

srt-58

-

314

7-transmembrane receptor

F40G9.11

mxl-2

-

315

bHLHZip transcription factor BIGMAX

W07G1.3

zip-3

-

352

Activating transcription factor 4

D1081.2

unc-120

353

331

Regulator of arginine metabolism and related MADS box-containing transcription factors

T27C4.4

egr-1

-

346

Histone deacetylase complex, MTA1 component

Y46H3D.6

nhr-237

-

432

Hormone receptors

C33G8.6

nhr-42

-

515

Hormone receptors

C49D10.2

nhr-166

-

529

Nuclear hormone receptor

T24A6.11

nhr-222

-

527

Nuclear hormone receptor

F45E4.9

hmg-5

-

540

HMG box-containing protein

H05G16.1

frm-3

-

655

Rho guanine nucleotide exchange factor CDEP

T22H6.6

gei-3

-

643

HMG-box transcription factor Capicua and related proteins

C10G8.7

ceh-33

608

670

Transcription factor SIX and related HOX domain proteins

C10G8.6

ceh-34

354

671

Transcription factor SIX and related HOX domain proteins

B0414.2

rnt-1

91

667

Runt and related transcription factors

Y46H3D.7

nhr-238

-

695

Hormone receptors

ZC64.3

ceh-18

-

685

Transcription factor OCT-1, contains POU and HOX domains

F44E2.6

-

746

Predicted pilin-like transcription factor

F41B5.9

nhr-182

-

849

Hormone receptors

B0304.1

hlh-1

142

83

Myogenic helix-loop-helix transcription factor

R13A5.5

ceh-13

324

-

Transcription factor zerknullt and related HOX domain proteins

F28B12.2

egl-44

451

-

TEF-1 and related transcription factor, TEAD family

T14G12.4

fkh-2

433

-

Transcription factor of the Forkhead/HNF3 family

F38A6.3

hif-1

564

-

Hypoxia-inducible factor 1/Neuronal PAS domain protein NPAS1

C37F5.1

lin-1

25

-

Predicted transcription factor

R03E9.1

mdl-1

378

-

Upstream transcription factor 2/L-myc-2 protein

Y5H2B.2

nhr-13

594

-

Hormone receptors

F58G6.5

nhr-34

715

-

Hormone receptors

T23H4.2

nhr-69

186

-

Hepatocyte nuclear factor 4 and similar steroid hormone receptors

Y68A4A.6

srz-96

625

-

7-transmembrane receptor

K10D3.3

taf-11.2

452

-

Transcription initiation factor TFIID, subunit TAF11

Y65B4BR.5

250

-

Transcription factor containing NAC and TS-N domains

K06A9.2

518

-

(F-box protein, contains homeobox domain)

Neuromuscular junction

F09E8.7

lev-1

631

173

Acetylcholine receptor

C35C5.5

lev-8

84

757

Acetylcholine receptor

T08G11.5

unc-29

70

400

Acetylcholine receptor

F21F3.5

unc-38

441

427

Acetylcholine receptor

Y110A7A.3

unc-63

-

78

Acetylcholine receptor

ZC504.2

acr-8

623

749

Acetylcholine receptor

F25G6.3

acr-16

-

42

Acetylcholine receptor

T21C12.1

unc-49

416

-

GABA receptor

K06C4.6

mod-1

-

806

Ligand-gated ion channel

C27H5.8

glc-4

770

-

Ligand-gated ion channel

T24D8.1

-

65

Ligand-gated ion channel

T27A1.4

199

807

Ligand-gated ion channel

Y113G7A.5

752

-

Ligand-gated ion channel

F22A3.3

glr-8

248

-

Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits

ZK867.2

593

-

(similar to glutamate receptor)


Fox et al. Genome Biology 2007 8:R188   doi:10.1186/gb-2007-8-9-r188

Open Data