Table 1 |
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|
Gene families enriched in muscle cells |
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|
Cosmid Name |
Common Name |
Rank M0 |
Rank M24 |
KOG (or other description) |
|
|
|
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|
Muscle |
K12F2.1 |
myo-3 |
710 |
240 |
Myosin class II heavy chain |
|
structure and function |
F11C3.3 |
unc-54 |
- |
431 |
Myosin class II heavy chain |
|
Y11D7A.14 |
- |
826 |
Myosin class II heavy chain |
||
|
F45G2.2 |
- |
743 |
Myosin class II heavy chain |
||
|
C36E6.3 |
mlc-1 |
93 |
156 |
Myosin regulatory light chain, EF-Hand protein superfamily |
|
|
C36E6.5 |
mlc-2 |
329 |
189 |
Myosin regulatory light chain, EF-Hand protein superfamily |
|
|
F09F7.2 |
mlc-3 |
279 |
246 |
Myosin essential light chain, EF-Hand protein superfamily |
|
|
F07A5.7 |
unc-15 |
18 |
298 |
Myosin class II heavy chain |
|
|
ZK617.1 |
unc-22 |
493 |
245 |
Projectin/twitchin and related proteins |
|
|
W06H8.8 |
ttn-1 |
168 |
534 |
Projectin/twitchin and related proteins |
|
|
F54E2.3 |
ketn-1 |
6 |
154 |
Unnamed Protein (Invertebrate Titin-like protein) |
|
|
K03E6.6 |
pfn-3 |
64 |
94 |
Profilin |
|
|
K06A4.3 |
584 |
389 |
Actin regulatory proteins (gelsolin/villin family) |
||
|
Y71G12B.11 |
4 |
122 |
Talin |
||
|
W03F11.6 |
afd-1 |
- |
393 |
Actin filament-binding protein Afadin |
|
|
F08A8.6 |
tag-138 |
- |
474 |
Actin-binding protein SLA2/Huntingtin-interacting protein Hip1 |
|
|
Y66H1B.3 |
462 |
784 |
Actin-binding cytoskeleton protein, filamin |
||
|
Y66H1B.2 |
119 |
902 |
Actin-binding cytoskeleton protein, filamin |
||
|
R01H10.3 |
cor-1 |
766 |
20 |
Actin-binding protein Coronin, contains WD40 repeats |
|
|
Y105E8B.1 |
lev-11 |
530 |
508 |
Actin filament-coating protein tropomyosin |
|
|
F42E11.4 |
tni-1 |
120 |
215 |
Troponin I |
|
|
ZK721.2 |
unc-27 |
236 |
111 |
Troponin I |
|
|
T20B3.2 |
tni-3 |
311 |
235 |
Troponin I |
|
|
T22E5.5 |
mup-2 |
230 |
166 |
Troponin |
|
|
C14F5.3 |
tnt-3 |
173 |
281 |
Troponin |
|
|
ZC477.9 |
deb-1 |
13 |
271 |
Alpha-catenin |
|
|
ZK1058.2 |
pat-3 |
99 |
- |
Integrin beta subunit (N-terminal portion of extracellular region) |
|
|
C29F9.7 |
pat-4 |
428 |
401 |
Integrin-linked kinase |
|
|
F54C1.7 |
pat-10 |
184 |
53 |
Calmodulin and related proteins (EF-Hand superfamily) |
|
|
C47E8.7 |
unc-112 |
436 |
559 |
Mitogen inducible gene product (contains ERM and PH domains) |
|
|
C18A11.7 |
dim-1 |
108 |
74 |
Immunoglobin and related proteins |
|
|
K11C4.5 |
unc-68 |
438 |
318 |
(Ryanodine receptor, Ca2+ release channel) |
|
|
K11D9.2 |
sca-1 |
192 |
31 |
Ca2+ transporting ATPase |
|
|
C18E9.1 |
cal-2 |
470 |
547 |
Calmodulin and related proteins (EF-Hand superfamily) |
|
|
C54E10.2 |
- |
578 |
Ca2+ sensor (EF-Hand superfamily) |
||
|
F21A10.1 |
760 |
650 |
Ca2+ sensor (EF-Hand superfamily) |
||
|
K03E6.3 |
ncs-3 |
659 |
185 |
Ca2+ sensor (EF-Hand superfamily) |
|
|
F40E10.3 |
csq-1 |
157 |
234 |
Calsequestrin |
|
|
Dystrophin glycoprotein complex |
F15D3.1 |
dys-1 |
265 |
869 |
Dystrophin-like protein |
|
C33G3.1 |
dyc-1 |
187 |
774 |
Muscular protein implicated in muscular dystrophy phenotype |
|
|
F30A10.8 |
stn-1 |
626 |
476 |
Syntrophins (type beta) |
|
|
F07H5.2 |
sgn-1 |
275 |
121 |
Gamma/delta sarcoglycan |
|
|
K01A2.1 |
sgcb-1 |
210 |
640 |
(Beta-sarcoglycan) |
|
|
H22K11.4 |
415 |
35 |
Sarcoglycan complex, alpha/epsilon subunits |
||
|
F27D9.8 |
stn-2 |
92 |
- |
Syntrophin (type gamma) |
|
|
T03F7.1 |
snf-11 |
507 |
644 |
(Sodium-neurotransmitter symporter) |
|
|
Transcription factors |
Y47D3B.7 |
sbp-1 |
326 |
7 |
Predicted DNA-binding protein |
|
F46G10.6 |
mxl-3 |
556 |
8 |
Upstream transcription factor 2/L-myc-2 protein |
|
|
T20B3.3 |
srh-215 |
- |
52 |
Predicted olfactory G-protein coupled receptor |
|
|
T26C11.1 |
tbx-41 |
- |
127 |
TBX2 and related T-box transcription factors |
|
|
T04C10.4 |
atf-5 |
- |
175 |
Activating transcription factor 4 |
|
|
C29G2.5 |
srt-58 |
- |
314 |
7-transmembrane receptor |
|
|
F40G9.11 |
mxl-2 |
- |
315 |
bHLHZip transcription factor BIGMAX |
|
|
W07G1.3 |
zip-3 |
- |
352 |
Activating transcription factor 4 |
|
|
D1081.2 |
unc-120 |
353 |
331 |
Regulator of arginine metabolism and related MADS box-containing transcription factors |
|
|
T27C4.4 |
egr-1 |
- |
346 |
Histone deacetylase complex, MTA1 component |
|
|
Y46H3D.6 |
nhr-237 |
- |
432 |
Hormone receptors |
|
|
C33G8.6 |
nhr-42 |
- |
515 |
Hormone receptors |
|
|
C49D10.2 |
nhr-166 |
- |
529 |
Nuclear hormone receptor |
|
|
T24A6.11 |
nhr-222 |
- |
527 |
Nuclear hormone receptor |
|
|
F45E4.9 |
hmg-5 |
- |
540 |
HMG box-containing protein |
|
|
H05G16.1 |
frm-3 |
- |
655 |
Rho guanine nucleotide exchange factor CDEP |
|
|
T22H6.6 |
gei-3 |
- |
643 |
HMG-box transcription factor Capicua and related proteins |
|
|
C10G8.7 |
ceh-33 |
608 |
670 |
Transcription factor SIX and related HOX domain proteins |
|
|
C10G8.6 |
ceh-34 |
354 |
671 |
Transcription factor SIX and related HOX domain proteins |
|
|
B0414.2 |
rnt-1 |
91 |
667 |
Runt and related transcription factors |
|
|
Y46H3D.7 |
nhr-238 |
- |
695 |
Hormone receptors |
|
|
ZC64.3 |
ceh-18 |
- |
685 |
Transcription factor OCT-1, contains POU and HOX domains |
|
|
F44E2.6 |
- |
746 |
Predicted pilin-like transcription factor |
||
|
F41B5.9 |
nhr-182 |
- |
849 |
Hormone receptors |
|
|
B0304.1 |
hlh-1 |
142 |
83 |
Myogenic helix-loop-helix transcription factor |
|
|
R13A5.5 |
ceh-13 |
324 |
- |
Transcription factor zerknullt and related HOX domain proteins |
|
|
F28B12.2 |
egl-44 |
451 |
- |
TEF-1 and related transcription factor, TEAD family |
|
|
T14G12.4 |
fkh-2 |
433 |
- |
Transcription factor of the Forkhead/HNF3 family |
|
|
F38A6.3 |
hif-1 |
564 |
- |
Hypoxia-inducible factor 1/Neuronal PAS domain protein NPAS1 |
|
|
C37F5.1 |
lin-1 |
25 |
- |
Predicted transcription factor |
|
|
R03E9.1 |
mdl-1 |
378 |
- |
Upstream transcription factor 2/L-myc-2 protein |
|
|
Y5H2B.2 |
nhr-13 |
594 |
- |
Hormone receptors |
|
|
F58G6.5 |
nhr-34 |
715 |
- |
Hormone receptors |
|
|
T23H4.2 |
nhr-69 |
186 |
- |
Hepatocyte nuclear factor 4 and similar steroid hormone receptors |
|
|
Y68A4A.6 |
srz-96 |
625 |
- |
7-transmembrane receptor |
|
|
K10D3.3 |
taf-11.2 |
452 |
- |
Transcription initiation factor TFIID, subunit TAF11 |
|
|
Y65B4BR.5 |
250 |
- |
Transcription factor containing NAC and TS-N domains |
||
|
K06A9.2 |
518 |
- |
(F-box protein, contains homeobox domain) |
||
|
Neuromuscular junction |
F09E8.7 |
lev-1 |
631 |
173 |
Acetylcholine receptor |
|
C35C5.5 |
lev-8 |
84 |
757 |
Acetylcholine receptor |
|
|
T08G11.5 |
unc-29 |
70 |
400 |
Acetylcholine receptor |
|
|
F21F3.5 |
unc-38 |
441 |
427 |
Acetylcholine receptor |
|
|
Y110A7A.3 |
unc-63 |
- |
78 |
Acetylcholine receptor |
|
|
ZC504.2 |
acr-8 |
623 |
749 |
Acetylcholine receptor |
|
|
F25G6.3 |
acr-16 |
- |
42 |
Acetylcholine receptor |
|
|
T21C12.1 |
unc-49 |
416 |
- |
GABA receptor |
|
|
K06C4.6 |
mod-1 |
- |
806 |
Ligand-gated ion channel |
|
|
C27H5.8 |
glc-4 |
770 |
- |
Ligand-gated ion channel |
|
|
T24D8.1 |
- |
65 |
Ligand-gated ion channel |
||
|
T27A1.4 |
199 |
807 |
Ligand-gated ion channel |
||
|
Y113G7A.5 |
752 |
- |
Ligand-gated ion channel |
||
|
F22A3.3 |
glr-8 |
248 |
- |
Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits |
|
|
ZK867.2 |
593 |
- |
(similar to glutamate receptor) |
||
|
|
|||||
|
Fox et al. Genome Biology 2007 8:R188 doi:10.1186/gb-2007-8-9-r188 |
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